Abstract:
Objective
To analyze and monitor the characteristics of peripheral inflammatory factors and coagulation function indexes in patients with Parkinson's disease complicated with Helicobacter pylori (Hp) infection and their correlation with the disease condition, and to explore the relationship between Hp and the disease course of Parkinson's disease.
Methods
From March 2021 to March 2023, 70 Parkinson's disease patients admitted to Fuyang Fifth People's Hospital were included as the observation group, and 50 healthy individuals undergoing physical examination during the same period were selected as the control group, and all participants underwent the 13C urea breath test.According to the occurrence of Hp infection in the observation group, patients were divided into the Hp infection group(n=41) and the non-Hp infection group (n=29), the levels of peripheral inflammatory factors [interleukin(IL)-1β, IL-6, IL-10, tumor necrosis factor-α (TNF-α)] and coagulation function indicators [prothrombin time, thrombin time (TT), activated partial thromboplastin time (APTT), and fibrinogen (FIB)] were compared between different groups, at the same time, Hoehn-Yahr (H-Y) rating scale, unified Parkinson's disease rating scale (UPDRS) Ⅲ and Ⅳ were used to evaluate the severity of the patients' disease and motor function status, and to analyze Hp infection and the changes in the characteristics of peripheral inflammatory factors and coagulation function indicators of Parkinson's disease.Sprearman model was used to analyze the correlation between Hp infection and the severity of Parkinson's disease.
Results
IL-1β,IL-6, IL-10, TNF-α and FIB in observation group were higher than those in control group, and TT and APTT were lower than those in control group, with statistically significant differences (P<0.05).There were no statistically significant differences in age, body mass index, hypertension, diabetes, drinking history, smoking history and positive 13C breath test between the two groups (P>0.05).IL-1β, IL-6, IL-10,TNF-α and FIB in Hp infection group were higher than those in non-Hp infection group, and TT and APTT were lower than those in non-Hp infection group, with statistically significant differences (P<0.05).There were no statistically significant differences in age, body mass index, hypertension, diabetes, drinking history and smoking history between the two groups (P>0.05).H-Y grading scale, UPDRS-Ⅲ and UPDRS-Ⅳ scores of Hp infection group were higher than those of non-Hp infection group, and the severity ratio of disease was also higher than that of non-Hp infection group, with statistical significant differences (P<0.05).Sprearman analysis showed that Hp infection was positively correlated with the severity of Parkinson's disease (r=0.483, P<0.05).
Conclusions
Hp infection in patients with Parkinson's disease is closely related to inflammatory state and coagulation dysfunction, and is positively correlated with the severity of Parkinson's disease.For people with Parkinson's disease, controlling Hp infection may help improve inflammatory symptoms and disease management.
Key words:
Parkinson's disease,
Helicobacter pylori,
Inflammatory factors,
Coagulation function
Qi Liu, Ping Chen, Xiaoxuan Cao, Mei Zhou, Binqiang Zhang, Wenbo Zhu. Study on the correlation between Hp infection and disease progression, peripheral inflammatory factors, coagulation function indicators in Parkinson's disease patients[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2025, 15(03): 262-266.