To explore the effects of Saccharomyces boulardii sachets combined with montmorillonite powder in the treatment of norovirus enteritis on clinical symptoms and intestinal microecology.

A total of 96 patients with norovirus enteritis admitted to Changzhi Maternal and Child Health Hospital from January 2024 to January 2025 were retrospectively selected as the study subjects. They were randomly divided into a control group of 48 cases and an observation group of 48 cases using a random number table method. Based on the clinical symptoms of the child, basic treatments such as fluid replacement, correction of electrolyte imbalance and regulation of acid-base balance were provided, and dietary guidance was also given. The control group was treated with montmorillonite powder, while the observation group was treated with montmorillonite powder and Saccharomyces boulardii sachets. The clinical symptoms, gut microbiota, gastrointestinal hormones, and inflammation levels between two groups were compared.

The observation group had shorter stopping time for diarrhea, vomiting, and fever compared to the control group (P<0.05). After 5 days of treatment, the numbers of Faecalibacterium in both groups increased, while the numbers of Enterococcus and Escherichia coli decreased. Compared with the control group, the number of Faecalibacterium increased more significantly in the observation group, while the number of Enterococcus and Escherichia coli decreased more significantly (P<0.05). Compared with before treatment, both groups showed a decrease in gastrin and glucagon after 5 days of treatment (P<0.05). After 5 days of treatment, the observation group showed a more significant decrease in gastrin and glucagon levels (P<0.05). After 5 days of treatment, the levels of serum procalcitonin, C-reactive protein (CRP), and interleukin-6 (IL-6) in both groups were lower than those before treatment (P<0.05). Compared with the control group, the observation group showed a more significant decrease in procalcitonin, CRP and IL-6 after 5 days of treatment (P<0.05).

The combination of Saccharomyces boulardii sachets and montmorillonite powder can effectively promote clinical symptom relief, regulate the intestinal microbiota level of children with norovirus enteritis, inhibit the body's inflammatory response.