To explore the application effect of flurbiprofen axetil (FA) combined with transverse abdominal muscle plane (TAP) block in anesthesia for laparoscopic radical resection of colorectal cancer (LRRCC) and its influences on the levels of serum cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9).

A total of 110 patients who underwent radical surgery for LRRCC at the No.215 Hospital of Shaanxi Nuclear Industry were selected. and randomly divided into the TAP group (TAP block anesthesia) and the FA group (FA combined with TAP block anesthesia). The anesthetic effects of two group and the changes in the levels of serum COX-2 and MMP-9 in patients were compared.

The FA group had earlier postoperative first exhaust time, defecation time, and time for getting out of bed for activities than the TAP group (P<0.05). At 6 h, 12 h and 24 h after surgery, the FA group had a lower Visual Analogue Scale (VAS) score than the TAP group (P<0.05), and a higher Ramsay sedation score than the TAP group (P<0.05). At 1 day after surgery, the FA group had lower levels of serum prostaglandin E2 (PGE2), β-endorphin (β-EP), COX-2 and MMP-9 than the TAP group (P<0.05). The FA group had fewer times of postoperative remedial analgesia than the TAP group (P<0.05), but there was no statistically significant difference in adverse reactions between the FA group and the TAP group (P>0.05).

FA combined with TAP block has a good application effect in the anesthesia of radical resection of LRRCC. It can significantly reduce the levels of serum COX-2 and MMP-9 in the early postoperative period, effectively inhibit the acute phase inflammatory stress response, and has good safety.