Value of combined application of color Doppler flow imaging and shear wave elastography in the diagnosis and fibrosis staging of non-alcoholic fatty liver disease

doi:10.3877/cma.j.issn.2095-2015.2026.04.006

Abstract

Abstract:

Objective

To explore the value of the combined application of color Doppler flow imaging (CDFI) and shear wave elastography (SWE) in the diagnosis and fibrosis staging of non-alcoholic fatty liver disease (NAFLD).

Methods

This study was a retrospective cohort study. A total of 80 cases of patients with NAFLD admitted to Honghui Hospital, Xi'an Jiaotong University from August 2022 to August 2025 were selected as the observation group, and 80 healthy individuals who underwent physical examinations in our hospital during the same period were selected as the control group. The liver CDFI examination parameter [portal vein main inner diameter (PVD), portal vein mean blood flow velocity (PVVmean), portal vein blood flow (PVQ), splenic vein inner diameter (SVD), splenic vein mean blood flow velocity (SVVmean), splenic vein blood flow (SVQ)] and SWE (Young's modulus value) between the two groups were compared, the occurrence of liver fibrosis in the observation group was recorded, and the liver CDFI examination parameter and SWE results of patients with different degrees of liver fibrosis were compared. The receiver regression curve (ROC) was used to analyze the diagnostic value of liver CDFI and SWE for NAFLD and liver fibrosis respectively.

Results

The PVD, PVQ, SVD, SVQ and Young's modulus values in the observation group were greater than those in the control group, while the PVVmean and SVVmean were lower than those in the control group (P<0.05). In the observation group, there were 40 cases of liver fibrosis in stage S0, 26 cases in stage S1, 9 cases in stage S2, 3 cases in stage S3, and 2 cases in stage S4, and the comparisons of PVD, PVVmean, PVQ, SVD, SVVmean, and SVQ among patients with different liver fibrosis grades revealed statistically significant differences (P<0.05). ROC analysis showed that the area under the curve (AUC) of liver CDFI parameters combined with SWE for diagnosing NAFLD was higher than that of single detection, and the AUC of liver CDFI parameters combined with SWE for diagnosing liver fibrosis in NAFLD patients was also higher than that of single detection (P<0.05).

Conclusion

Liver CDFI combined with SWE has a high diagnostic value for both NAFLD and liver fibrosis, and should be closely monitored in clinical practice.

Key words: Non-alcoholic fatty liver disease, Color Doppler flow imaging, Portal vein, Splenic vein, Shear wave elastography, Diagnostic value

Tian Hu, Zhimin Hou, Yilun Wu. Value of combined application of color Doppler flow imaging and shear wave elastography in the diagnosis and fibrosis staging of non-alcoholic fatty liver disease[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2026, 16(04): 319-324.

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Figures/Tables 6

References 20

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组别	例数	性别[例(%)]		年龄(岁,±s)	体重指数(kg/m²,±s)	吸烟[例(%)]	饮酒[例(%)]	高血压[例(%)]	糖尿病[例(%)]	冠心病[例(%)]
组别	例数	男	女	年龄(岁,±s)	体重指数(kg/m²,±s)	吸烟[例(%)]	饮酒[例(%)]	高血压[例(%)]	糖尿病[例(%)]	冠心病[例(%)]
观察组	80	51(63.75)	29(36.25)	51.72±6.61	24.34±3.02	36(45.00)	20(25.00)	33(41.25)	17(21.25)	24(30.00)
对照组	80	54(67.50)	26(32.50)	50.03±7.51	23.95±3.11	28(35.00)	16(20.00)	24(30.00)	18(22.50)	19(23.75)
χ²/t值		0.249		1.511	0.805	1.667	0.574	2.208	0.037	0.795
P值		0.618		0.133	0.422	0.197	0.449	0.137	0.848	0.373

组别	例数	性别[例(%)]		年龄(岁,±s)	体重指数(kg/m²,±s)	吸烟[例(%)]	饮酒[例(%)]	高血压[例(%)]	糖尿病[例(%)]	冠心病[例(%)]
组别	例数	男	女	年龄(岁,±s)	体重指数(kg/m²,±s)	吸烟[例(%)]	饮酒[例(%)]	高血压[例(%)]	糖尿病[例(%)]	冠心病[例(%)]
观察组	80	51(63.75)	29(36.25)	51.72±6.61	24.34±3.02	36(45.00)	20(25.00)	33(41.25)	17(21.25)	24(30.00)
对照组	80	54(67.50)	26(32.50)	50.03±7.51	23.95±3.11	28(35.00)	16(20.00)	24(30.00)	18(22.50)	19(23.75)
χ²/t值		0.249		1.511	0.805	1.667	0.574	2.208	0.037	0.795
P值		0.618		0.133	0.422	0.197	0.449	0.137	0.848	0.373

组别	例数	PVD(cm)	PVVmean(cm/s)	PVQ(mL/min)	SVD(cm)	SVVmean(cm/s)	SVQ(mL/min)	杨氏模量(kPa)
观察组	80	1.33±0.30	13.43±2.02	1123.50±222.01	1.04±0.25	18.18±3.01	845.29±140.91	9.63±2.81
对照组	80	1.10±0.20	18.05±2.27	1009.58±121.10	0.75±0.12	23.39±2.81	646.49±98.20	4.62±1.51
t值		5.706	13.599	4.029	9.354	11.317	10.353	14.047
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别	例数	PVD(cm)	PVVmean(cm/s)	PVQ(mL/min)	SVD(cm)	SVVmean(cm/s)	SVQ(mL/min)	杨氏模量(kPa)
观察组	80	1.33±0.30	13.43±2.02	1123.50±222.01	1.04±0.25	18.18±3.01	845.29±140.91	9.63±2.81
对照组	80	1.10±0.20	18.05±2.27	1009.58±121.10	0.75±0.12	23.39±2.81	646.49±98.20	4.62±1.51
t值		5.706	13.599	4.029	9.354	11.317	10.353	14.047
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

肝纤维化分期	例数	PVD(cm)	PVVmean(cm/s)	PVQ(mL/min)	SVD(cm)	SVVmean(cm/s)	SVQ(mL/min)	杨氏模量(kPa)
S0期	40	1.15±0.21	14.73±1.04	1029.35±131.12	0.88±0.11	20.20±1.86	771.58±102.03	7.92±0.92
S1期	26	1.37±0.20^a	12.96±1.66^a	1116.19±82.83^a	1.10±0.16^a	17.31±1.52^a	867.62±89.74^a	9.80±1.00^a
S2期	9	1.59±0.16^ab	11.11±1.17^ab	1314.78±217.02^ab	1.26±0.10^ab	15.56±1.81^ab	941.33±74.72^ab	12.01±1.38^ab
S3期	3	1.90±0.10^abc	10.33±0.58^abc	1526.67±58.29^abc	1.53±0.15^abc	12.33±0.58^abc	1103.33±26.27^abc	15.00±1.61^abc
S4期	2	2.25±0.21^abcd	8.50±0.71^abcd	1616.00±24.04^abcd	1.85±0.21^abcd	9.50±0.71^abcd	1210.00±32.58^abcd	22.70±0.56^abcd
F值		27.722	30.270	40.798	54.341	42.592	32.689	128.616
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

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