Cirrhosis is a diffuse liver injury caused by long-term or repeated action of one or more etiologies.Liver transplantation is an effective treatment for decompensated cirrhosis.However, due to liver source tension and other factors, most patients with cirrhosis are at risk of life due to complications such as upper gastrointestinal bleeding, hepatic encephalopathy, secondary infection and cancer.Stem cell therapy can improve cirrhosis of the liver.Transplantation of autologous bone marrow into the liver via portal vein is more beneficial to the survival and proliferation of stem cells in the liver.More than 150 patients with decompensated liver cirrhosis are treated by autologous bone marrow transplantation via portal vein, and the results show that the liver function is improved, the liver volume is increased, and the hardness of liver is decreased.