Abstract:
Objective To assess the value of material separation technical of spectral CT in evaluating the efficacy of urate-lowering therapy in early-stage gouty arthritis patients.
Methods The clinical and imaging data of 32 early-stage gouty arthritis patients were retrospectively analyzed.Spectral CT scan was conducted on the foot before and after the therapy.Selected uric acid-calcium as basics, two radiologists performed material separation on spectral CT images, and measured the concentration of uric acid around the first metatarsophalangeal joint on uric acid based mapping.The differences of concentration of uric acid and serum uric acid levels before and after treatment were compared by paired t test respectively.Spearman correlation coefficient was used to analyze the association between changes in serum urate levels and spectral CT results.
Results Before the therapy, the mean concentration of uric acid was(1 178.78±11.63)mg/L, mean serum urate level was(421.59±115.27)μmol/L; after the treatment, the mean concentration of uric acid was(1 162.55±9.50)mg/L, mean serum urate level was(309.41±87.59)μmol/L.Compared to the former data, the concentration of uric acid and serum urate level were significantly lower after treatment(P<0.01; P<0.01). The decrease in serum urate levels was positively related to the decrease in the concentration of uric acid on the uric acid based mapping(r=0.53, P<0.01).
Conclusion The spectral CT can evaluate the efficacy of urate-lowering therapy quantitatively through comparing the concentration of uric acid around the first metatarsophalangeal joint in early-stage gouty arthritis, and it can provide more quantitative data for clinical treatment and monitoring.
Key words:
Gouty arthritis,
Spectral CT,
Urate-lowering therapy,
Response evaluation
Yun Peng, Meng Wang, Xianfu Luo, Qingqiang Zhu, Jingtao Wu. Quantitative evaluation of the efficacy of urate-lowering therapy with spectral CT imaging in early-stage gouty arthritis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2020, 10(02): 58-61.