Research progress of nonalcoholic fatty pancreas disease

doi:10.3877/cma.j.issn.2095-2015.2022.01.011

Abstract

Abstract:

Nonalcoholic fatty pancreas disease(NAFPD)refers to the accumulation of pancreatic fat related to obesity or metabolic syndrome.In recent years, with the improvement of people′s living standards, its incidence is also increasing, and the related research is also increasing.At present, its pathogenesis is unclear, and the quantitative evaluation methods mainly include histological examination, ultrasound, CT, MRI, etc.According to studies in recent years, its correlation with diseases mainly focuses on type 2 diabetes, atherosclerosis, metabolic syndrome, pancreatic cancer, pancreatic endocrine and exocrine function, nonalcoholic fatty liver, acute and chronic pancreatitis, pancreatic fistula and so on.Compared with hepatic steatosis, the number of studies related to NAFPD is still small.

Key words: Nonalcoholic fatty pancreas disease, Fatty pancreas, Metabolic syndrome, Research progress

Ying Xu, Xiaohong Ma, Xinming Zhao. Research progress of nonalcoholic fatty pancreas disease[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(01): 46-51.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhxhbyyxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-2015.2022.01.011

https://zhxhbyyxzz.cma-cmc.com.cn/EN/Y2022/V12/I01/46

Figures/Tables 1

References 67

1	Ogilvie RF.The islands of langerhans in 19 cases of obesity [J]．J Pathol Bacteriol，1933，37(3)：473-481.
2	Wang CY,，Ou HY,，CHEN MF，et al.Enigmatic ectopic fat：prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population [J]．J Am Heart Assoc，2014，3(1)：e000297.
3	Zhou J,，Li ML,，Zang DD，et al.The correlation between pancreatic steatosis and metabolic syndrome in a Chinese population [J]．Pancreatology，2016，16(4)：578-583.
4	Dite P,，Blaho M,，Bojkova M，et al.Nonalcoholic Fatty Pancreas Disease：Clinical Consequences [J]．Dig Dis，2020，38(2)：143-149.
5	Smits MM,，Van Geenen EJ.The clinical significance of pancreatic steatosis [J]．Nat Rev Gastroenterol Hepatol，2011，8(3)：169-177.
6	Catanzaro R,，Cuffari B,，Italia A，et al.Exploring the metabolic syndrome：Nonalcoholic fatty pancreas disease [J]．World J Gastroenterol，2016，22(34)：7660-7675.
7	Bobulescu IA,，Lotan Y,，Zhang J，et al.Triglycerides in the human kidney cortex：relationship with body size [J]．PLoS One，2014，9(8)：e101285.
8	Van GEENEN EJ,，Smits MM,，Schreuder TC，et al.Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease [J]．Pancreas，2010，39(8)：1185-1190.
9	Carter R,，Mouralidarane A,，Soeda J，et al.Non-alcoholic fatty pancreas disease pathogenesis：a role for developmental programming and altered circadian rhythms [J]．PLoS One，2014，9(3)：e89505.
10	Lingvay I,，Esser V,，Legendre JL，et al.Noninvasive quantification of pancreatic fat in humans [J]．J Clin Endocrinol Metab，2009，94(10)：4070-4076.
11	Olsen TS.Lipomatosis of the pancreas in autopsy material and its relation to age and overweight [J]．Acta Pathol Microbiol Scand A，1978，86A(5)：367-373.
12	Stamm BH.Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy：a systematic study of 112 autopsies in patients without known pancreatic disease [J]．Hum Pathol，1984，15(7)：677-683.
13	Saisho Y,，Butler AE,，Meier JJ，et al.Pancreas volumes in humans from birth to age one hundred taking into account sex，obesity，and presence of type-2 diabetes [J]．Clin Anat，2007，20(8)：933-942.
14	Midiri M,，Lo Casto A,，Sparacia G，et al.MR imaging of pancreatic changes in patients with transfusion-dependent beta-thalassemia major [J]．AJR Am J Roentgenol，1999，173(1)：187-192.
15	Robertson MB,，Choe KA,，Joseph PM.Review of the abdominal manifestations of cystic fibrosis in the adult patient [J]．Radiographics，2006，26(3)：679-690.
16	Raeder H,，Haldorsen IS,，Ersland L，et al.Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase [J]．Diabetes，2007，56(2)：444-449.
17	Daentl DL,，Frias JL,，Gilbert EF，et al.The Johanson-Blizzard syndrome：case report and autopsy findings [J]．Am J Med Genet，1979，3(2)：129-135.
18	Walters MN.Adipose atrophy of the exocrine pancreas [J]．J Pathol Bacteriol，1966，92(2)：547-557.
19	Fullenkamp AM,，Bell LN,，Robbing RD，et al.Effect of different obesogenic diets on pancreatic histology in Ossabaw miniature swine [J]．Pancreas，2011，40(3)：438-443.
20	Grippo PJ,，Fitchev PS,，Bentrem DJ，et al.Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice [J]．Gut，2012，61(10)：1454-1464.
21	Lee Y,，Lingvay I,，Szczepaniak LS，et al.Pancreatic steatosis：harbinger of type 2 diabetes in obese rodents [J]．Int J Obes(Lond)，2010，34(2)：396-400.
22	Oben J A,，Patel T,，Mouralidarane A，et al.Maternal obesity programmes offspring development of non-alcoholic fatty pancreas disease [J]．Biochem Biophys Res Commun，2010，394(1)：24-28.
23	Belyaev O,，Munding J,，Herzog T，et al.Histomorphological features of the pancreatic remnant as independent risk factors for postoperative pancreatic fistula：a matched-pairs analysis [J]．Pancreatology，2011，11(5)：516-524.
24	Gaujoux S,，Cortes A,，Couvelard A，et al.Fatty pancreas and increased body mass index are risk factors of pancreatic fistula after pancreaticoduodenectomy [J]．Surgery，2010，148(1)：15-23.
25	Hori M,，Takahashi M,，Hiraoka N，et al.Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma [J]．Clin Transl Gastroenterol，2014，5：e53.
26	Kim SY,，Kim H,，Cho JY，et al.Quantitative assessment of pancreatic fat by using unenhanced CT：pathologic correlation and clinical implications [J]．Radiology，2014，271(1)：104-112.
27	Rebours V,，Gaujoux S,，D′Assignies G，et al.Obesity and Fatty Pancreatic Infiltration Are Risk Factors for Pancreatic Precancerous Lesions(PanIN)[J]．Clin Cancer Res，2015，21(15)：3522-3528.
28	Van Geenen EJ,，Smits MM,，Schreuder TC，et al.Smoking is related to pancreatic fibrosis in humans [J]．Am J Gastroenterol，2011，106(6)：1161-1166.
29	Matsumoto S,，Mori H,，Miyake H，et al.Uneven fatty replacement of the pancreas：evaluation with CT [J]．Radiology，1995，194(2)：453-458.
30	Jeong HT,，Lee MS,，Kim MJ.Quantitative analysis of pancreatic echogenicity on transabdominal sonography：correlations with metabolic syndrome [J]．J Clin Ultrasound，2015，43(2)：98-108.
31	Lee JS,，Kim SH,，Jun DW，et al.Clinical implications of fatty pancreas：correlations between fatty pancreas and metabolic syndrome [J]．World J Gastroenterol，2009，15(15)：1869-1875.
32	Ustundag Y,，Ceylan G,，Hekimoglu K．Pancreatic hyperechogenicity on endoscopic ultrasound examination [J]．World J Gastroenterol，2011，17(15)：2061-2062.
33	Navina S,，Acharya C,，Delany JP，et al.Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity [J]．Sci Transl Med，2011，3(107)：107ra10.
34	Mathur A,，Hernandez J,，Shaheen F，et al.Preoperative computed tomography measurements of pancreatic steatosis and visceral fat：prognostic markers for dissemination and lethality of pancreatic adenocarcinoma [J]．HPB(Oxford)，2011，13(6)：404-410.
35	Roberts K J,，Storey R,，Hodson J，et al.Pre-operative prediction of pancreatic fistula：is it possible? [J]．Pancreatology，2013，13(4)：423-428.
36	Ly JN,，Miller FH.MR imaging of the pancreas：a practical approach [J]．Radiol Clin North Am，2002，40(6)：1289-1306.
37	Gaborit B,，Abdesselam I,，Kober F，et al.Ectopic fat storage in the pancreas using 1H-MRS：importance of diabetic status and modulation with bariatric surgery-induced weight loss [J]．Int J Obes(Lond)，2015，39(3)：480-487.
38	Hannukainen JC,，Borra R,，Linderborg K，et al.Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity [J]．J Hepatol，2011，54(3)：545-552.
39	Hu HH,，Kim H W,，Nayak KS，et al.Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans [J]．Obesity(Silver Spring)，2010，18(4)：841-847.
40	Begovatz P,，Koliaki C,，Weber K，et al.Pancreatic adipose tissue infiltration，parenchymal steatosis and beta cell function in humans [J]．Diabetologia，2015，58(7)：1646-1655.
41	Ma J,，Song Z,，Yan F．Detection of hepatic and pancreatic fat infiltration in type II diabetes mellitus patients with IDEAL-Quant using 3.0T MR：comparison with single-voxel proton spectroscopy [J]．Chin Med J(Engl)，2014，127(20)：3548-3552.
42	Schwenzer NF,，Machann J,，Martirosian P，et al.Quantification of pancreatic lipomatosis and liver steatosis by MRI：comparison of in/opposed-phase and spectral-spatial excitation techniques [J]．Invest Radiol，2008，43(5)：330-337.
43	Yu H,，Shimakawa A,，Mckenzie CA，et al.Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling [J]．Magn Reson Med，2008，60(5)：1122-1134.
44	Ou HY,，Wang CY,，Yang YC，et al.The association between nonalcoholic fatty pancreas disease and diabetes [J]．PLoS One，2013，8(5)：e62561.
45	Tushuizen ME,，Bunck MC,，Pouwels PJ，et al.Pancreatic fat content and beta-cell function in men with and without type 2 diabetes [J]．Diabetes Care，2007，30(11)：2916-2921.
46	Heni M,，Machann J,，Staiger H，et al.Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance：a nuclear magnetic resonance study [J]．Diabetes Metab Res Rev，2010，26(3)：200-205.
47	Van Raalte DH,，Van DER ZIJL NJ,，Diamant M．Pancreatic steatosis in humans：cause or marker of lipotoxicity? [J]．Curr Opin Clin Nutr Metab Care，2010，13(4)：478-485.
48	Szendroedi J,，Roden M．Ectopic lipids and organ function [J]．Curr Opin Lipidol，2009，20(1)：50-56.
49	Kul S,，Karadeniz A,，Dursun I，et al.Non-Alcoholic Fatty Pancreas Disease is Associated with Increased Epicardial Adipose Tissue and Aortic Intima-Media Thickness [J]．Acta Cardiol Sin，2019，35(2)：118-125.
50	Alberti KG,，Eckel RH,，Grundy SM，et al.Harmonizing the metabolic syndrome：a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention；National Heart，Lung，and Blood Institute；American Heart Association；World Heart Federation；International Atherosclerosis Society；and International Association for the Study of Obesity [J]．Circulation，2009，120(16)：1640-1645.
51	Bi Y,，Wang JL,，Li M L，et al.The association between pancreas steatosis and metabolic syndrome：A systematic review and meta-analysis [J]．Diabetes Metab Res Rev，2019，35(5)：e3142.
52	Tomita Y,，Azuma K,，Nonaka Y，et al.Pancreatic fatty degeneration and fibrosis as predisposing factors for the development of pancreatic ductal adenocarcinoma [J]．Pancreas，2014，43(7)：1032-1041.
53	Zyromski NJ,，Mathur A,，Pitt HA，et al.Obesity potentiates the growth and dissemination of pancreatic cancer [J]．Surgery，2009，146(2)：258-263.
54	Lesmana CRA,，Gani RA,，Lesmana LA.Non-alcoholic fatty pancreas disease as a risk factor for pancreatic cancer based on endoscopic ultrasound examination among pancreatic cancer patients：A single-center experience [J]．JGH Open，2018，2(1)：4-7.
55	Wu Q,，Chen G,，Wu WM，et al.Metabolic syndrome components and risk factors for pancreatic adenocarcinoma：a case-control study in China [J]．Digestion，2012，86(4)：294-301.
56	Abbruzzese JL,，Andersen DK,，Borrebaeck CAK，et al.The Interface of Pancreatic Cancer With Diabetes，Obesity，and Inflammation：Research Gaps and Opportunities：Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop [J]．Pancreas，2018，47(5)：516-525.
57	Philip B,，Roland CL,，Daniluk J，et al.A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice [J]．Gastroenterology，2013，145(6)：1449-1458.
58	Desai V,，Patel K,，Sheth R，et al.Pancreatic Fat Infiltration Is Associated with a Higher Risk of Pancreatic Ductal Adenocarcinoma [J]．Visc Med，2020，36(3)：220-226.
59	Mathur A,，Zyromski N J,，Pitt H A，et al.Pancreatic steatosis promotes dissemination and lethality of pancreatic cancer [J]．J Am Coll Surg，2009，208(5)：989-994.
60	Savvina T V．[A histotopographic study of the pancreas in lipomatosis][J]．Arkh Patol，1976，38(1)：68-73.
61	Miyake H,，Sakagami J,，Yasuda H，et al.Association of fatty pancreas with pancreatic endocrine and exocrine function [J]．PLoS One，2018，13(12)：e0209448.
62	Pezzilli R,，Andriulli A,，Bassi C，et al.Exocrine pancreatic insufficiency in adults：a shared position statement of the Italian Association for the Study of the Pancreas [J]．World J Gastroenterol，2013，19(44)：7930-7946.
63	Tahtaci M,，Algin O,，Karakan T，et al.Can pancreatic steatosis affect exocrine functions of pancreas? [J]．Turk J Gastroenterol，2018，29(5)：588-594.
64	Acharya C,，Cline RA,，Jaligama D，et al.Fibrosis reduces severity of acute-on-chronic pancreatitis in humans [J]．Gastroenterology，2013，145(2)：466-475.
65	Ronti T,，Lupattelli G,，Mannarino E．The endocrine function of adipose tissue：an update [J]．Clin Endocrinol(Oxf)，2006，64(4)：355-365.
66	Zyromski NJ,，Mathur A,，Pitt HA，et al.A murine model of obesity implicates the adipokine milieu in the pathogenesis of severe acute pancreatitis [J]．Am J Physiol Gastrointest Liver Physiol，2008，295(3)：G552-558.
67	Honka H,，Koffert J,，Hannukainen JC，et al.The effects of bariatric surgery on pancreatic lipid metabolism and blood flow [J]．J Clin Endocrinol Metab，2015，100(5)：2015-2023.

胰腺脂肪变性胰腺脂肪增多症脂肪性胰腺	胰腺脂肪沉积的通用术语
脂肪替代	腺泡细胞死亡(例如由于血色沉着病、病毒感染或导管阻塞)-脂肪细胞替代(不可逆)
脂肪浸润	由于肥胖或NAFPD引起的脂肪细胞浸润(可逆)
非酒精性脂肪性胰腺疾病(nonalcoholic fatty pancreas disease, NAFPD)	与肥胖、代谢综合征相关的胰腺脂肪堆积
非酒精性脂肪性胰腺炎(nonalcoholic fatty steatopancreatitis, NASP)	胰腺脂肪堆积引起的胰腺炎

胰腺脂肪变性胰腺脂肪增多症脂肪性胰腺	胰腺脂肪沉积的通用术语
脂肪替代	腺泡细胞死亡(例如由于血色沉着病、病毒感染或导管阻塞)-脂肪细胞替代(不可逆)
脂肪浸润	由于肥胖或NAFPD引起的脂肪细胞浸润(可逆)
非酒精性脂肪性胰腺疾病(nonalcoholic fatty pancreas disease, NAFPD)	与肥胖、代谢综合征相关的胰腺脂肪堆积
非酒精性脂肪性胰腺炎(nonalcoholic fatty steatopancreatitis, NASP)	胰腺脂肪堆积引起的胰腺炎

[1]	Yongbo Zhang, Liang Zhang, Liuyang Chen, Rui Dai, Hua Sun, Sheng Yang, Bo Meng, Qing Peng. Mitochondrial and intervertebral disc degeneration [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(03): 265-269.
[2]	Yijun Fan, Feng Yang, Wei Wang, Heying Yin, Jun Liu. Research progress in the diagnostic and therapeutic value of Delphian lymph node metastasis in papillary thyroid carcinoma [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(04): 306-310.
[3]	Xiyan Zheng, Zheng Zhou, Fangping He, Zhiqun Lin, Fei Du, Qin Xie, Shaoping Wang, Xianjie Shi. Risk factors for the prognosis of metabolic syndrome and hepatitis B virus related hepatocellular carcinoma [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(02): 104-109.
[4]	Binru Zhang, Hua Chen, Bei Sun. Status and prospect of pancreaticojejunostomy in pancreaticoduodenectomy [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2022, 16(04): 465-468.
[5]	Fuhao Qin, Zheng Zheng, Bin Jiang. Research progress of mesenchymal stem cells in the treatment of perianal fifistulizing Crohn's disease [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(03): 172-177.
[6]	Junjie Huang, Lie Wang, Hu Zhao, Yin Xia, Zaizhong Zhang. Progress in the mechanism of lncRNA as ceRNA involved in the pathogenesis and progression of infantile hemangioma [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(06): 360-366.
[7]	Bing Lan, Huaiming Wang, Hui Wang, Bo Ma. Research progress on locally advanced colon cancer with bladder invasion [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(06): 505-511.
[8]	Hengyu Luan, Xiaoyong Sai. Treatment status and research progress of post-traumatic stress disorder [J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(02): 112-118.
[9]	Wenpeng Huang, Yongkang Qiu, Qi Yang, Lele Song, Zhao Chen, Yan Fan, Lei Kang. Research progress of PET related radiomics in tumor prognosis [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(02): 104-110.
[10]	Ying Xu, Feng Ye, Xinming Zhao. Research progress of application of dual-energy computed tomography in radiological diagnosis of liver diseases [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(04): 241-245.
[11]	Zhiwei Liu, Liting Zhao, Zhirong Yu, Youpeng Chen. Relationship between metabolic syndrome and colorectal tubular villous adenoma [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(04): 215-219.
[12]	Yihan Wu, Zhang Lei, Hongda Lu. Progress in understanding of role of MUC16/CA125 in diagnosis and treatment of benign and malignant tumors [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(05): 591-595.
[13]	Lianchao Jin, Bing Yang, Zhe Zhou, Dongliang Pan, Zunke Xie. Correlation of metabolic syndrome and stress urinary incontinence in women [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2023, 09(02): 109-113.
[14]	Shijin Liu, Yiran Zhang, Hui Ding, Xiaoxu Zhao, Yunlong Pan. Metabolic syndrome and telomere status in the prognosis of patients with colorectal cancer [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(04): 231-235.
[15]	Ze Wang, Baojun Wang, Weize Zhang. Research progress in stroke rehabilitation [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(04): 221-224.

Please choose a citation manager

Content to export