To analyze the relationship between colorectal tubular villous adenoma and metabolic syndrome

A total of 271 patients with surgical and pathological diagnosis in Huiyang Hospital Affiliated to Southern Medical University from June 2017 to December 2020 were collected. There were 203 cases of tubular adenoma and 68 cases of tubular villous adenoma. The basic information of fibercolonoscopy, general characteristics, number, pathology and metabolic syndrome related indexes of colorectal polyps were compared between tubular adenoma and tubular villous adenoma patients. Logistic regression analysis was used to analyze the relationship between Yamada classification, maximum polyp diameter, metabolic syndrome related indexes and colorectal tubular villous adenoma.

The site with the largest cumulative number of polyps, the most prone site of polyps, and the common sites of tubular villous adenoma and tubular adenoma were sigmoid colon. The differences between the patients with colorectal tubular adenoma and tubular villous adenoma were statistically significant in Yamada classification, maximum polyp diameter, serum triglyceride (all P<0.01), but there were no statistically significant differences in hypertension, fatty liver, impaired fasting glucose or diabetes, total cholesterol, serum uric acid level and carcinoembryonic antigen level. Logistic regression analysis showed that Yamada classification [Wald χ²=5.756, Exp(B)=2.494, P=0.016] and maximum polyp diameter [Wald χ²=23.173, Exp(B)=12.842, P<0.001] were correlated with colorectal tubular villous adenoma, but serum triglyceride level was not correlated with colorectal tubular villous adenoma.

Compared with patients with tubular adenoma, metabolic syndrome is not directly related to the pathogenesis of colorectal tubular villous adenoma, but polyp diameter and Yamada classification are closely related to the pathogenesis of colorectal tubular villous adenoma.