Abstract:

Objective

To investigate the relationship between the changes of serum intestinal fatty acid binding protein (I-FABP), high mobility group protein B1 (HMGB1), T lymphocyte subsets and the severity of disease in children with rotavirus enteritis (RE).

Methods

A total of 210 children with RE admitted to Yulin First Hospital from April 2021 to April 2024 were selected as the study group, according to the severity of dehydration, the children were divided into mild to moderate group (n=151) and severe group (n=59), and 180 healthy children were selected as the control group.The changes of I-FABP,HMGB1 and T lymphocyte subsets in serum of all groups were compared, Pearson correlation analysis was used to analyze the correlation between the changes of serum I-FABP, HMGB1 and T lymphocyte subsets and the severity of RE in children.

Results

The levels of I-FABP, HMGB1 and CD8⁺ in study group were significantly higher than those in control group, while the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in study group were significantly lower than those in control group (P<0.05); the levels of I-FABP, HMGB1 and CD8⁺ in severe group were significantly higher than those in mild to moderate group, while the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ were significantly lower than those in mild to moderate group (P<0.05).The results of Pearson correlation analysis showed that the serum levels of I-FABP, HMGB1 and CD8⁺ were positively correlated with the severity of the disease, while the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ were negatively correlated with the severity of the disease (P<0.05).

Conclusion

The levels of I-FABP,HMGB1, and T lymphocyte subsets in the serum of children with RE are closely related to the severity of the condition, and monitoring these indicators can provide an important reference for the evaluation and treatment of children with RE.

Key words: Rotavirus enteritis, Intestinal fatty acid binding protein, High mobility group protein B1, T lymphocyte subsets, Severity of the illness