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中华消化病与影像杂志(电子版) ›› 2021, Vol. 11 ›› Issue (05) : 193 -195. doi: 10.3877/cma.j.issn.2095-2015.2021.05.001

临床研究

上海市嘉定区炎症性肠病患者的粪便钙卫蛋白检测研究
杨翠萍1, 全旭1, 孙顺昌1, 张梦茵1, 张金叶1, 贾颖1, 俞骁珺1, 谢玲1, 蔡波尔1, 吴云林1, 陈平1,()   
  1. 1. 201801 上海交通大学医学院附属瑞金医院消化内科
  • 收稿日期:2021-02-11 出版日期:2021-10-01
  • 通信作者: 陈平

Study of fecal calprotectin detection in patients with inflammatory bowel disease in Jiading district of Shanghai of China

Cuiping Yang1, Xu Quan1, Shunchang Sun1, Mengyin Zhang1, Jinye Zhang1, Ying Jia1, Xiaojun Yu1, Ling Xie1, Bo′er Cai1, Yunlin Wu1, Ping Chen1,()   

  1. 1. Department of Gastroenterology, Ruijin Hospital of School of Medicine of Shanghai Jiaotong University, Shanghai 201801, China
  • Received:2021-02-11 Published:2021-10-01
  • Corresponding author: Ping Chen
引用本文:

杨翠萍, 全旭, 孙顺昌, 张梦茵, 张金叶, 贾颖, 俞骁珺, 谢玲, 蔡波尔, 吴云林, 陈平. 上海市嘉定区炎症性肠病患者的粪便钙卫蛋白检测研究[J]. 中华消化病与影像杂志(电子版), 2021, 11(05): 193-195.

Cuiping Yang, Xu Quan, Shunchang Sun, Mengyin Zhang, Jinye Zhang, Ying Jia, Xiaojun Yu, Ling Xie, Bo′er Cai, Yunlin Wu, Ping Chen. Study of fecal calprotectin detection in patients with inflammatory bowel disease in Jiading district of Shanghai of China[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2021, 11(05): 193-195.

目的

探讨粪便钙卫蛋白(FC)在上海市嘉定地区炎症性肠病患者临床诊断中的意义。

方法

选取2020年3月至2020年5月上海瑞金医院北部院区43例研究对象的粪便样本,分成2组,炎症性肠病(IBD)组28例和健康对照组15例。采用荧光免疫层析法定量检测粪便中FC浓度。

结果

15例健康者FC浓度为(40.63)μg /g,28例IBD患者平均为(323.45)μg /g。IBD患者与健康者FC浓度比较有显著差别(P<0.05)。以60 μg /g为临界值时,FC判断IBD是否活动的灵敏度和特异度分别为82.14%和86.67%,活动期IBD患者与静止期IBD患者和健康者FC浓度比较均也有显著差异(P<0.05)。

结论

FC检测作为一种非侵入性诊疗方法,可作为内镜下诊断疾病活动性的一种替代指标,在上海嘉定地区诊断IBD以及评估疾病活动性具有良好的应用价值。

Objective

To investigate the value of fecal calprotectin(FC)in the diagnosis of patients with inflammatory bowel disease(IBD)in Jiading district of Shanghai of China.

Methods

The fecal samples of 43 subjects from March 2020 to May 2020 in North District of Shanghai Ruijin Hospital were collected and divided into two groups: IBD group(n=28)and healthy control group(n=15). Fluorescence immunochromatography was used to quantitatively detect FC concentration in feces.

Results

The FC concentration in 15 healthy subjects was 40.63 μg/g, and that in 28 patients with was 323.45 μg/g.There was a significant difference in FC concentration between IBD group and control group(P<0.05). When 60 μg/g was taken as the critical value, the sensitivity and specificity of FC to determine whether IBD was active or not were 82.14% and 86.67%, respectively.There were also significant differences in FC concentrations between active IBD patients and inactive IBD patients and healthy subjects(P<0.05).

Conclusion

FC test, as a non-invasive diagnosis and treatment method, can be used as an alternative index for endoscopic diagnosis of disease activity, which has a good application value in the diagnosis of IBD and the assessment of disease activity in Jiading district of Shanghai of China.

表1 炎症性肠病患者与健康者粪便钙卫蛋白浓度比较(μg/g)
表2 活动期和静止期炎症性肠病患者的粪便钙卫蛋白浓度比较(μg/g)
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