切换至 "中华医学电子期刊资源库"

中华消化病与影像杂志(电子版) ›› 2024, Vol. 14 ›› Issue (02) : 141 -145. doi: 10.3877/cma.j.issn.2095-2015.2024.02.008

论著

术前血浆纤维蛋白原、血脂水平及MMR表达与结直肠癌病理特点及预后的相关性
朱菡1, 卓士超1,(), 吴迪1, 朱雅楠2, 韩佳欣3   
  1. 1. 221000 江苏省,徐州市中心医院病理科
    2. 221000 江苏省,徐州医科大学附属医院甲乳外科
    3. 325000 浙江省,温州医科大学
  • 收稿日期:2023-09-22 出版日期:2024-04-01
  • 通信作者: 卓士超

Correlation between preoperative plasma fibrinogen, blood lipid level, MMR expression and pathological characteristics and prognosis of colorectal cancer

Han Zhu1, Shichao Zhuo1,(), Di Wu1, Yanan Zhu2, Jiaxin Han3   

  1. 1. Department of Pathology, Xuzhou Central Hospital, Xuzhou 221000, China
    2. Department of Thyroid and Breast Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China
    3. Wenzhou Medical University, Wenzhou 325000, China
  • Received:2023-09-22 Published:2024-04-01
  • Corresponding author: Shichao Zhuo
引用本文:

朱菡, 卓士超, 吴迪, 朱雅楠, 韩佳欣. 术前血浆纤维蛋白原、血脂水平及MMR表达与结直肠癌病理特点及预后的相关性[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(02): 141-145.

Han Zhu, Shichao Zhuo, Di Wu, Yanan Zhu, Jiaxin Han. Correlation between preoperative plasma fibrinogen, blood lipid level, MMR expression and pathological characteristics and prognosis of colorectal cancer[J/OL]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(02): 141-145.

目的

分析手术前血浆纤维蛋白原(FIB)、血脂水平及DNA错配修复(MMR)表达与结直肠癌病理特点及预后质量的相关性。

方法

纳入徐州市中心医院2018年3月至2020年9月收治的226例结直肠癌患者,比较不同病理特点、不同预后质量患者一般资料和术前血浆FIB、血脂及肿瘤组织和癌旁组织MMR表达情况,使用Logistic多因素回归分析,总结影响患者病理特点和预后质量的相关因素。

结果

Logistic多因素回归分析示,FIB、脂蛋白a[LP(a)]、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇(L/H)升高,病灶MMR、癌旁MMR高度或低度微卫星不稳定性(MSI),以及HDL-C下降均是结直肠癌患者TNM分期上升、3年死亡的独立危险因素;甘油三酯(TC)、载脂蛋白(ApoA)、L/H、病灶MMR、癌旁MMR高度或低度MSI,以及HDL-C下降是结直肠癌的独立危险因素(P<0.05)。

结论

术前血浆FIB、血脂水平及MMR表达差异,与结直肠癌患者TNM分期、病灶部位和预后质量密切相关。

Objective

To analyze the correlation between preoperative plasma fibrinogen (FIB), blood lipid level and DNA mismatch repair (MMR) expression and pathological characteristics and prognosis quality of colorectal cancer.

Methods

A total of 226 patients with colorectal cancer admitted to Xuzhou Central Hospital from March 2018 to September 2020 were included. The general data and the preoperative plasma FIB, blood lipid and MMR expression in tumor tissues and adjacent tissues of patients with different pathological characteristics and different prognosis quality were compared. Logistic multivariate regression analysis was used to summarize the related factors affecting the pathological characteristics and prognosis quality of patients.

Results

Logistic multivariate regression analysis showed that the increase of FIB, lipoprotein a [LP(a)] and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (L/H), MMR of the lesion, the high or low microsatellite instability (MSI) of MMR adjacent to cancer, and the decrease of HDL-C were independent risk factors for TNM staging increase and 3-year death in patients with colorectal cancer. triglyceride (TC), apolipoprotein (ApoA), L/H, MMR of the lesion, high or low MSI of MMR adjacent to cancer, and decrease of HDL-C were independent risk factors for colorectal cancer (P<0.05).

Conclusion

The difference of plasma FIB, blood lipid level and MMR expression before operation are closely related to TNM staging, lesion location and prognosis quality of colorectal cancer patients.

表1 不同TNM分期患者一般资料和检测结果比较
表2 不同病灶部位患者一般资料和检测结果比较
表3 不同预后质量患者一般资料和检测结果比较
表4 影响结直肠癌患者TNM分期的多因素回归分析结果
表5 影响结直肠癌患者病灶部位的多因素回归分析结果
表6 影响结直肠癌患者预后质量的多因素回归分析结果
[1]
潘思琼, 陆奉科, 李山. 错配修复蛋白MLH1, MSH2, PMS2, MSH6及p53在结直肠癌中的表达及意义[J]. 海南医学, 2021, 32(1): 4-7.
[2]
Fathi M, Pustokhina I, Kuznetsov SV, et al. T-cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer[J]. IUBMB Life, 2021, 73(5): 726-738.
[3]
梁俏, 周喜汉. 肿瘤相关成纤维细胞在结直肠癌中的研究进展[J]. 世界华人消化杂志, 2023, 31(4): 134-142.
[4]
武爱文, 李英杰. 结直肠癌新辅助免疫治疗的应用现状以及争议和挑战[J]. 中华胃肠外科杂志, 2022, 25(3): 185-192.
[5]
Saridemir S, Güven H E, Aksel B, et al. Serum AMDL DR-70 levels: a new concept in the diagnosis and follow-up of colorectal carcinoma[J]. Biomarkers in Medicine, 2020, 14(8): 621-628.
[6]
袁明俊, 江滨, 皇甫少华, 等. 具核梭杆菌促进结直肠癌发生发展机制的研究进展[J]. 中国微生态学杂志, 2023, 35(4): 481-484.
[7]
张津玮, 黄孙桦, 秦建民. 结直肠癌肝转移转化治疗的临床策略与手术治疗[J]. 世界华人消化杂志, 2022, 30(20): 897-913.
[8]
Yerlikaya A, Zeren S. Molecular Pathways, Targeted Therapies, and Proteomic Investigations of Colorectal Cancer[J]. Curr Mol Med, 2023, 23(1): 2-12.
[9]
宋德心, 王伟东, 高瑞祺, 等. 肠道菌群在结直肠癌发生发展和诊断治疗中的作用研究进展[J]. 中国普通外科杂志, 2022, 31(4): 527-536.
[10]
Porter RJ, Arends MJ, Churchhouse AMD, et al. Inflammatory bowel disease-associated colorectal cancer: translational risks from mechanisms to medicines[J]. J Crohns Colitis, 2021, 15(12): 2131-2141.
[11]
Hachey SJ, Movsesyan S, Nguyen QH, et al. An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy[J]. Lab Chip, 2021, 21(7): 1333-1351.
[12]
张琪, 李健, 沈琳, 等. 结直肠癌与微卫星不稳定的十个临床问题[J/OL]. 肿瘤综合治疗电子杂志, 2020, 6(3): 75-84.
[13]
Cantor DI, Cheruku HR, Westacott J, et al. Proteomic investigations into resistance in colorectal cancer[J]. Expert Rev Proteomics, 2020, 17(1): 49-65.
[14]
王轶卓, 王畅. BRAF突变转移性结直肠癌临床分子特征及治疗进展[J/OL]. 肿瘤综合治疗电子杂志, 2020, 6(4): 82-86.
[15]
Robles González MA, Villaseñor MP, Alfaro Cruz A, et al. Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor[J]. Case Rep Gastroenterol, 2022, 16(3): 652-662.
[16]
Mo S, Cai X, Zhou Z, et al. Nomograms for predicting specific distant metastatic sites and overall survival of colorectal cancer patients: a large population-based real-world study[J]. Clin Transl Med, 2020, 10(1): 169-181.
[17]
王赫, 史新龙, 李晶晶, 等. 肠道菌群与结直肠肿瘤关系的研究进展[J]. 中国普通外科杂志, 2020, 29(10): 1261-1269.
[18]
Fujiwara Y, Yamaguchi T, Nakane M. Portal vein thrombosis in metastatic colorectal cancer during FOLFIRI-bevacizumab chemotherapy successfully treated with apixaban[J]. Int Med, 2021, 60(1): 53-57.
[19]
Yamashita R, Long J, Longacre T, et al. Deep learning model for the prediction of microsatellite instability in colorectal cancer: a diagnostic study[J]. Lancet Oncol, 2021, 22(1): 132-141.
[20]
张冬生, 封益飞, 王勇, 等. 微卫星不稳定状态与结直肠癌患者临床病理特征的相关性研究[J/OL]. 中华结直肠疾病电子杂志, 2021, 10(2): 132-136.
[1] 许杰, 李亚俊, 韩军伟. 两种入路下腹腔镜根治性全胃切除术治疗超重胃癌的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 19-22.
[2] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[3] 李代勤, 刘佩杰. 动态增强磁共振评估中晚期低位直肠癌同步放化疗后疗效及预后的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 100-103.
[4] 关小玲, 周文营, 陈洪平. PTAAR在乙肝相关慢加急性肝衰竭患者短期预后中的预测价值[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 841-845.
[5] 张润锦, 阳盼, 林燕斯, 刘尊龙, 刘建平, 金小岩. EB病毒相关胆管癌伴多发转移一例及国内文献复习[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 865-869.
[6] 陈晓鹏, 王佳妮, 练庆海, 杨九妹. 肝细胞癌VOPP1表达及其与预后的关系[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 876-882.
[7] 刘郁, 段绍斌, 丁志翔, 史志涛. miR-34a-5p 在结肠癌患者的表达及其与临床特征及预后的相关性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 485-490.
[8] 王国强, 张纲, 唐建坡, 张玉国, 杨永江. LINC00839 调节miR-17-5p/WEE1 轴对结直肠癌细胞增殖、凋亡和迁移的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 491-499.
[9] 孙晗, 于冰, 武侠, 周熙朗. 基于循环肿瘤DNA 甲基化的结直肠癌筛查预测模型的构建与验证[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 500-506.
[10] 陈倩倩, 袁晨, 刘基, 尹婷婷. 多层螺旋CT 参数、癌胚抗原、错配修复基因及病理指标对结直肠癌预后的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 507-511.
[11] 曾明芬, 王艳. 急性胰腺炎合并脂肪肝患者CT 与彩色多普勒超声诊断参数与其病情和预后的关联性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 531-535.
[12] 沈炎, 张俊峰, 唐春芳. 预后营养指数结合血清降钙素原、胱抑素C及视黄醇结合蛋白对急性胰腺炎并发急性肾损伤的预测价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 536-540.
[13] 王湛, 李文坤, 杨奕, 徐芳, 周敏思, 苏珈仪, 王亚丹, 吴静. 炎症指标在早发性结直肠肿瘤中的应用[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 802-810.
[14] 王景明, 王磊, 许小多, 邢文强, 张兆岩, 黄伟敏. 腰椎椎旁肌的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 846-852.
[15] 郭曌蓉, 王歆光, 刘毅强, 何英剑, 王立泽, 杨飏, 汪星, 曹威, 谷重山, 范铁, 李金锋, 范照青. 不同亚型乳腺叶状肿瘤的临床病理特征及预后危险因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 524-532.
阅读次数
全文


摘要