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Chinese Journal of Digestion and Medical Imageology(Electronic Edition) ›› 2017, Vol. 07 ›› Issue (04): 153-158. doi: 10.3877/cma.j.issn.2095-2015.2017.04.003

Special Issue:

• Clinical Science Research • Previous Articles     Next Articles

Effect of narrow band imaging magnifying endoscopy and endoscopic biopsy in the diagnosis of gastric cancer

Lihui Wang1, Wansheng Ji2, Hongsheng Dai1, Chunping Zhang1, Zhixing Gao2,()   

  1. 1. Weifang Medical University, Weifang 261042, China
    2. Department of Gastroenterology, Affiliated Hospital of Weifang Medical University, Weifang 261031, China
  • Received:2016-09-05 Online:2017-08-01 Published:2017-08-01
  • Contact: Zhixing Gao
  • About author:
    Corresponding author: Gao Zhixing, Email:

Abstract:

Objective

To explore the value and difference of narrow band imaging-magnifying endoscopy(NBI-ME)and endoscopic biopsy in the diagnosis of early gastric cancer and precancerous lesions.

Methods

Fifty patients with suspicious early gastric lesions or precancerous lesions as revealed by white light endoscopy(WLE)were enrolled in the study from March 2016 to June 2016 in Affiliated Hospital of Weifang Medical University.All lesions were observed through NBI-ME, and the types of crypt-opening were recorded to give a diagnosis.Biopsy specimens were then taken from suspicious lesions for pathological examination.All patients received endoscopic submucosal dissection(ESD)or surgical intervention.The types of crypt-opening were analyzed in combination with postoperative pathological diagnosis.The diagnosis of NBI-ME and endoscopic biopsy and postoperative pathological diagnosis were compared and analyzed.

Results

There was significant difference in the type of crypt-opening and the postoperative pathological diagnosis(χ2=42.13, P<0.05). The sensitivity of NBI-ME for diagnosing low-grade intraepithelial neoplasia(LGIN)was significantly lower than that of endoscopic biopsy(P=0.02), but there was no statistical difference in diagnostic specificity and accuracy between the two modalities(P>0.05). The differences of sensitivity, specificity and accuracy between NBI-ME and endoscopic biopsy in the diagnosis of early gastric cancer were not statistically significant(P>0.05). The Kappa values of the consistency checks were 0.54(NBI-ME and postoperative pathological diagnosis)and 0.64(endoscopic biopsy and postoperative pathological diagnosis), with a statistically significant difference(P<0.05).

Conclusion

NBI-ME has a high clinical value in the diagnosis of early gastric cancer and precancerous lesions, but there are still differences compared with the results of pathological biopsy.NBI-ME can provide a great help to accurate endoscopic biopsy.

Key words: Gastric cancer, Precancerous lesion, Norrow-band imaging-magnifying endoscopy, Biopsy, Pathology

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