Infection rate of Helicobacter pylori in patients with gastroesophageal reflux disease: a Meta-analysis

doi:10.3877/cma.j.issn.2095-2015.2017.05.004

Abstract

Abstract:

Objective

To analyze 21 documents published in Chinese and foreign languages about Helicobacter pylori(Hp)and gastroesophageal reflux disease(GERD)in the past 15 years by Meta-analysis, and to investigate the relationship between Hp and GERD.

Methods

The Chinese and foreign literatures about Hp and GERD published from 2001 to 2016 were searched and screened through PubMed, Ovid, China National Knowledge Infrastructure(CNKI)and Wanfang Database.The data were analyzed by using Stata12.0 software.

Results

The analysis results of 21 studies showed that: ①The infection rate of Hp in GERD group was lower than that in the normal control group(OR=0.56, 95% CI: 0.46-0.68); ②The infection rate of Hp in erosive esophagitis(EE)typing of GERD was lower than that in the normal control group(OR=0.46, 95% CI: 0.35-0.61); ③The infection rate of Hp in Barrett′s esophagus(BE)typing of GERD was lower than that in the normal control group(OR=0.43, 95% CI: 0.30-0.62); ④There was no significant difference between LA-CD and LA-AB of EE(OR=0.39, 95% CI: 0.10-1.57).

Conclusions

The infection rate of Hp in GERD patients is lower than that in the normal people.We speculate that Hp may have a protective effect on GERD and not be relevant to the severity of EE.

Key words: Helicobacter pylori, Gastroesophageal reflux disease, Erosive esophagitis, Barrett′s esophagus, Meta-analysis

Yangyang Kong, Lixin Liu. Infection rate of Helicobacter pylori in patients with gastroesophageal reflux disease: a Meta-analysis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2017, 07(05): 205-210.

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Figures/Tables 5

References 23

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编号	第一作者	文献来源	国家
1	Wu JC	Aliment Pharmacol Ther，2001，15(12)：1913-1919.	中国
2	Garrido Serrano A	Revista Espanola de Enfermedades Digestivas，2003，95(11)：788-790, 785-787.	西班牙
3	Zentilin P	Aliment Pharmacol Ther，2003，17(8)：1057-1064.	意大利
4	Kim BC	Korean J Gastroenterol，2006，47(5)：363-369.	韩国
5	Corley DA	Gut，2008，57(6)：727-733.	美国
6	Klitorakis I	Rev Med Chir Soc Med Nat Iasi，2010，114(2)：363-366.	罗马尼亚
7	马许辉	中华实用诊断与治疗杂志，2011，25(12)：1238-1239.	中国
8	Chung SJ	J Neurogastroenterol Motil, 2011，17(3)：267-273.	韩国
9	Ashktorab H	Dig Dis Sci，2012，57(11)：2924-2928.	美国
10	Thrift AP	Int J Cancer, 2012，130(10)：2407-2416.	澳大利亚
11	Polat FR	JSLS，2012，16(2)：260-263.	土耳其
12	Chiba H	Int Med, 2012，51(11)：1293-1299.	日本
13	Gashi Z	Med Arch，2013，67(6)：402-404.	科索瓦
14	Rubenstein JH	Clin Gastroenterol Hepatol，2014，12(2)：239-245.	美国
15	Chihiro M	PLoS One, 2013，8(7)：e69891.	日本
16	王雯(Wen W)	解放军医学杂志，2011，36(8)：860-862.	中国
17	Khalid K	J Dig Dis，2007，8(4)：203-206.	约旦
18	Inomata	Am J Gastroenterol，2006，101(5)：926-933.	日本
19	Carmona-Sánchez R	Revista De Gastroenterología De México，2003，68(1)：23-28.	西班牙
20	Rajendra S	Helicobacter，2007，12(2)：177-183.	马来西亚
21	Loffeld RJ	Neth J Med，2004 ，62(6)：188-191.	荷兰

编号	第一作者	文献来源	国家
1	Wu JC	Aliment Pharmacol Ther，2001，15(12)：1913-1919.	中国
2	Garrido Serrano A	Revista Espanola de Enfermedades Digestivas，2003，95(11)：788-790, 785-787.	西班牙
3	Zentilin P	Aliment Pharmacol Ther，2003，17(8)：1057-1064.	意大利
4	Kim BC	Korean J Gastroenterol，2006，47(5)：363-369.	韩国
5	Corley DA	Gut，2008，57(6)：727-733.	美国
6	Klitorakis I	Rev Med Chir Soc Med Nat Iasi，2010，114(2)：363-366.	罗马尼亚
7	马许辉	中华实用诊断与治疗杂志，2011，25(12)：1238-1239.	中国
8	Chung SJ	J Neurogastroenterol Motil, 2011，17(3)：267-273.	韩国
9	Ashktorab H	Dig Dis Sci，2012，57(11)：2924-2928.	美国
10	Thrift AP	Int J Cancer, 2012，130(10)：2407-2416.	澳大利亚
11	Polat FR	JSLS，2012，16(2)：260-263.	土耳其
12	Chiba H	Int Med, 2012，51(11)：1293-1299.	日本
13	Gashi Z	Med Arch，2013，67(6)：402-404.	科索瓦
14	Rubenstein JH	Clin Gastroenterol Hepatol，2014，12(2)：239-245.	美国
15	Chihiro M	PLoS One, 2013，8(7)：e69891.	日本
16	王雯(Wen W)	解放军医学杂志，2011，36(8)：860-862.	中国
17	Khalid K	J Dig Dis，2007，8(4)：203-206.	约旦
18	Inomata	Am J Gastroenterol，2006，101(5)：926-933.	日本
19	Carmona-Sánchez R	Revista De Gastroenterología De México，2003，68(1)：23-28.	西班牙
20	Rajendra S	Helicobacter，2007，12(2)：177-183.	马来西亚
21	Loffeld RJ	Neth J Med，2004 ，62(6)：188-191.	荷兰

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