Diagnostic value of tuberculin test and T-cell spot test in intestinal tuberculosis

doi:10.3877/cma.j.issn.2095-2015.2020.04.007

Abstract

Abstract:

This article reviews the research progress of tuberculin test and T-cell spot test in the diagnosis of intestinal tuberculosis.The sensitivity of tuberculin test in the diagnosis of intestinal tuberculosis is about 50%-60%, the specificity can reach 70%, and the negative predictive value is 60%-70%.The T-cell spot test has a sensitivity of more than 70%, a specificity of more than 80%, and a negative predictive value of more than 80%in the diagnosis of intestinal tuberculosis.In the diagnosis of intestinal tuberculosis, the sensitivity can exceed 80%, the specificity can exceed 60%, and the negative predictive value can exceed 85%, which has high clinical significance for the diagnosis and differential diagnosis of intestinal tuberculosis.Therefore, theycan be used in combination according to clinical conditions.

Key words: Intestinal tuberculosis, Tuberculin test, T-cell spot test, Sensitivity, Specificity, Negative predictive value

Huijuan Wang, Yanran Liu, Xueliang Jiang. Diagnostic value of tuberculin test and T-cell spot test in intestinal tuberculosis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2020, 10(04): 174-177.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhxhbyyxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-2015.2020.04.007

https://zhxhbyyxzz.cma-cmc.com.cn/EN/Y2020/V10/I04/174

References 30

1	马晓菡，胡乃中．肠结核18例临床分析[J]．安徽医学，2019，40(9):1047-1049.
2	高翔.31例肠结核临床诊断分析[D]．合肥：安徽医科大学，2018.
3	邱志兵，钟良，杨海静，等．T细胞斑点试验在肠结核诊断的初步探讨[J]．中国感染与化疗杂志，2012，12(5):381-383.
4	陈玲，董秋华.60例肠结核患者临床特征及诊治体会[J]．西南国防医药，2018，28(8):758-760.
5	徐镇杰．克罗恩病与肠结核鉴别诊断的临床研究[D]．杭州：浙江大学，2017.
6	尹丹萍，刘同亭．克罗恩病与肠结核鉴别诊断的新进展[J/CD]．中华消化病与影像杂志(电子版)，2017，7(2):79-82.
7	饶日春，陈克文，谢建清，等.35例肠结核临床诊断分析[J]．结核病与肺部健康杂志，2016(4):327-332.
8	高翔，常家聪.31例肠结核临床诊断分析[J]．中国现代医学杂志，2018，28(22):126-128.
9	梁瓞绵，刘德良，吴小平，等．结核感染T细胞斑点试验诊断肠结核价值研究[J]．中国实用内科杂志，2014，34(11):1106-1108.
10	叶丽敏，李岚，白班俊．T细胞斑点试验在肠结核及克罗恩病鉴别诊断中的临床价值[J]．第三军医大学学报，2015，37(20):2091-2095.
11	南黄鑫，廖旺娣，朱萱，等．T-SPOT与PPD在肠结核与克罗恩病鉴别诊断中的临床价值[C].2012南方消化论坛暨第八届全国肠道疾病学术大会论文集，2012：1-1.
12	李红纳，孙勇.38例肠结核的临床分析[J]．中国医药指南，2017，15(16):137-138.
13	梁艳，王兰，张翠英，等两种γ干扰素释放试验及PPD试验结果在结核感染诊断中的比较[J]．中国防痨杂志，2015，37(7):740-747.
14	Shi XC，Zhang LF，Zhang YQ，et al.Clinical and Laboratory Diagnosis of Intestinal Tuberculosis[J]．Chin Med J，2016，129(11):1330-1333.
15	荣兰香，马淑红，艾清，刘天明．T.SPOT-TB试验与PPD试验对结核病患者诊断价值相关性比较[J]．中国实验诊断学，2013，17(8):1475-1476.
16	项时昊．肠结核15例诊断分析[D]．杭州：浙江大学，2006.
17	魏娟，施慧，陆恒，等．T-SPOT.TB与PPD在消化系统结核感染鉴别诊断中的价值[J]．胃肠病学和肝病学杂志，2014，23(3):289-291.
18	栾金龙.15例肠结核临床诊疗分析[D]．大连：大连医科大学，2014.
19	鄂秀英，曾忠仪，郭月瑜．局部加温对PPD试验结果的影响研究[J]．西部医学，2009，21(1):65-66.
20	Ninet B，Roux-Lombard P，Schrenzel J，et al.[New tests for the diagnosis of tuberculosis][J]．Revue Des Maladies Respiratoires，2011，28(6):823-833.
21	吴小君，何华英．月经期对结核菌素纯蛋白衍生物皮肤试验结果的影响[J]．中国乡村医药，2011，18(1):57.
22	施冰．克罗恩病与肠结核、原发性肠道淋巴瘤的鉴别诊断回顾性分析[D]．福州：福建医科大学，2016.
23	张群．T-SPOT.TB对结核病诊断敏感性及其影响因素的探讨[D]．济南：山东大学，2016.
24	夏青．结核感染T细胞斑点试验在结核病诊断中的价值及影响因素探讨[D]．合肥：安徽医科大学，2019.
25	余述凤，王学中．T-SPOT在肺结核中的诊断价值[J]．临床肺科杂志，2015(7):1237-1240.
26	吴琼，王堃，丘世飏，等．T细胞斑点试验在结核感染诊断中的临床应用[J]．中国医师杂志，2018，20(1):87-91.
27	刘浏，梁志忠，贾柳萍，等．结核感染T细胞斑点试验对鉴别克罗恩病和肠结核的临床价值[J]．中华实用诊断与治疗杂志，2014，28(6):570-571.
28	卢青纯，唐小燕，熊恬园，等．T-SPOT.TB试验在活动性结核诊断中的价值及其影响因家分析[J]．中国循证医学杂志，2014，14(5):522-526.
29	梅玫，罗雁，刘会领．肠结核实验室检查的临床应用进展[J]．国际检验医学杂志，2016，37(18):2587-2589.
30	Ng SC，Hirai HW，Tsoi KK，et al.Systematic review with meta-analysis：accuracy of interferon-gamma releasing assay and anti-S accharomyces cerevisiae antibody in differentiating intestinal tuberculosis from Crohn′s disease in Asians[J]．J Gastroen Hepatol，2014，29(9):1664-1670.

[1]	Haigang Niu, Wenke Guo. Expressions of dual specific phosphatase 14 and nuclear receptor interacting protein 1 in triple negative breast cancer and their prognostic value [J]. Chinese Journal of Breast Disease(Electronic Edition), 2024, 18(04): 199-205.
[2]	Yini Wang, Fan Yang, Mei Tang, Yun Xiang, Jinhui Wu, Hong Luo. Survey on current status of knowledge-attitudes-practices of clinical diagnosis and treatment of infant cow's milk protein allergy among pediatricians and analysis of its influencing factors [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(04): 420-430.
[3]	Xiangyang Zhao, Shuangchi Liu, Yigang Zhang, Tao Tao, Yi Tan. Study on programmed death ligand 1 expression and drug sensitivity of cisplatin in hepatocellular carcinoma Hep3B cells [J]. Chinese Archives of General Surgery(Electronic Edition), 2024, 18(01): 51-55.
[4]	Hua Zhang, Yu Sun, Shijian Xiang, Yingmei Li, Xiaoqun Wang. Research on chemosensitivity evaluation using circulating tumor cells in advanced gastrointestinal cancer [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(06): 422-425.
[5]	Yonghuan Mao, Ling Xi, Chen Lu, Lixiang Liu, Chunzhao Yu, Xiaofei Shen. PI3K/Akt signaling pathway influences the chemotherapy sensitivity of PANC-1 to gemcitabine in pancreatic cancer cells via Plk1 [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(02): 135-138.
[6]	Quanxi Li, Huijun Tang, Jiansheng Zhang, Fei Yang. Comparative study of multiplexed sensitivity-encoding diffusion weighted imaging and single-shot echo-planar diffusion weighted imaging in prostate cancer images [J]. Chinese Journal of Endourology(Electronic Edition), 2023, 17(06): 553-557.
[7]	Jing Zhao. Diagnostic value of high-frequency ultrasound on indirect inguinal hernia [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(05): 575-578.
[8]	Rui Zhang, Yanni Chen, Xiaotao Hou, Hao Chen, Qiyao Ma, Min Ni. Analysis of pressure measurement characteristics of functional outlet obstruction constipation with elderly patients [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(02): 139-144.
[9]	Qi Liu, Na Tu, Shuyong Jia, Yi Guo, Guangjun Wang. Research progress on mechanism of acupuncture and moxibustion based on EEG analysis [J]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2024, 13(02): 69-72.
[10]	Lei Zhu, Qingyi Zhu. Kingella: An emerging pathogen of invasive infections disease in young children [J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(04): 229-237.
[11]	Xia Zhang, Jitian Li, Wenqi Qin, Jie Zhou, Huiqin Tang. Establishment of clinical reportable range for detection of D-dimer by Sysmex CS-5100 automatic coagulation analyzer [J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(01): 27-32.
[12]	Shan Huang, Songqin Lyu, Juan Zhang, Liping Xu, Jianeng Li, Xiaofei Li. The preliminary research on the distribution characteristics of peripheral T lymphocytes subsets in new AIDS patients combined with other pathogenic microorganisms in Yunnan areas [J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2023, 11(01): 16-20.
[13]	Xiaoming Wu, Yangkui Zhai, Juan Wang, Shuo Zhang, Jie Xu, Congqing Pan. Association of fasting c-peptide and quantitative insulin sensitivity index with arteriosclerosis index of plasma in male patients with T2DM [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(04): 288-294.
[14]	Chunying Ou, Xiaobin Li, Jing Guo, Ke Xu, Meng Wang, Xiaolei An. Correlation of hs-CRP, Lp-PLA2, and S100β with vascular cognitive impairment in patients with ischemic small vascular disease [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(03): 265-269.
[15]	Tun Zhao, Jihua Xu, Youdi He, Ming Lu. Acute spontaneous trace amount cerebral hemorrhage misdiagnosed as cerebral infarction and nearly thrombolysis: a case report [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(04): 369-372.

Please choose a citation manager

Content to export