To investigate the role of low-dose CT perfusion imaging in the preoperative evaluation of differentiation degree of gastric cancer and its correlation with the expression of Her2 and EGFR in gastric cancer.

A total of 43 patients with gastric cancer were selected from August 2019 to January 2020 in Jiangsu Subei People′s Hospital.Low-dose 320-row multi-slice spiral CT perfusion scan was performed one week before surgery, and perfusion parameters were obtained, including blood flow(BF), blood volume(BV), capillary permeability(PS)and mean passage time(MTT). According to the postoperative pathological results, the poorly differentiated adenocarcinoma, signet-ring cell carcinoma and mucinous adenocarcinoma were divided into group A, and the moderately well-differentiated adenocarcinoma was divided into group B. According to the results of immunohistochemistry, EGFR expression(-)was the negative group, and EGFR expression(1+ , 2+ )was the positive group.The expression of Her2(0, 1+ )was the negative group, and the expression of Her2(3+ )was the positive group.SPSS19.0 software was used for calculation.

The values of BF, BV and PS were statistically different between group A and group B, and there was no significant correlation between the expression levels of Her2 and EGFR and the perfusion parameters.Meanwhile, the values of BF and PS were statistically different between the EGFR negative and positive groups.

CT perfusion imaging can obtain tumor internal blood flow perfusion from non-invasive in vitro.The perfusion parameters BF, BV and PS are of great significance in preoperative evaluation of gastric cancer differentiation, while the expression levels of Her2 and EGFR are poorly correlated with the perfusion parameters, which can be used as auxiliary observation indicators.