To investigate the application value of lobeline in digestive endoscopy intravenous anesthesia elderly patients.

A total of 200 elderly patients who were treated with digestive endoscopy under intravenous anesthesia in First People's Hospital of Xiaogan City from April 2018 to August 2020 were retrospectively analyzed. According to the random number table method, they were randomly divided into observation group and control group, with 100 cases in each group. The observation group was anesthetized with lobeline 3 mg + dezocine 0.05 mg/kg + propofol 1-2 mg/kg, and the control group was anesthetized with dezocine 0.05 mg/kg + propofol 1-2 mg/kg. After the eyelash reflex disappeared, and the bispectral index (BIS) value was 50-60, the treatment was carried out. Propofol 0.5 mg/kg was added intermittently during the operation according to the progress of treatment, and BIS value was maintained at 50-60. The mean arterial pressure (MAP), electrocardiogram (ECG), pulse oxygen saturation (SpO₂), BIS value and side flow end expiratory carbon dioxide partial pressure (PETCO₂) were routinely monitored. PETCO₂ value, SpO₂ value, awake time, time out of recovery room, incidences of apnea, hypoxemia and delayed recovery were measured at 1 min (T₁), 3 min (T₂), 5 min (T₃), 10 min (T₄) and 15 min (T₅) after anesthesia administration and compared between the two groups.

PETCO₂ and SpO₂ values of the observation group were higher than those of the control group at different time points after anesthesia administration, while the incidences of apnea and hypoxemia were lower than that of the control group, and there were statistically significant differences (P<0.05). There were no statistically significant differences in MAP, heart rate, postoperative recovery time, time out of recovery room and incidence of delayed recovery between the two groups (P>0.05).

Lobeline can effectively increase the respiratory amplitude and respiratory rate, maintain stable SpO₂, reduce the incidence of hypoxemia, and does not prolong the time of postoperative recovery and out of recovery room during short-term intravenous anesthesia with digestive endoscopy, with high safety.