Effects of Helicobacter pylori infection on microinflammation and nutritional status in maintenance hemodialysis patients

doi:10.3877/cma.j.issn.2095-2015.2021.06.007

Abstract

Abstract:

Objective

To investigate the Helicobacter pylori (Hp) infection in maintenance hemodialysis patients, and to explore the effects of Hp infection on microinflammation and nutritional status of the patients.

Methods

A total of 254 maintenance hemodialysis patients admitted to Huai'an Second People's Hospital from June 2019 to September 2020 were retrospectively analyzed. The Hp infection of the study subjects were analyzed, and the patients were grouped according to the presence or absence of Hp infection. After 3 months of treatment, the levels of tumor necrosis factor-α (TNF-α), serum interleukin-6 (IL-6) and hypersensitive C-reactive protein (hs-CRP) were measured to assess the microinflammatory status. Triceps skin fold thickness (TSF) was measured to assess fat storage. Body mass and serum nutritional indexes including albumin (ALB), prealbumin (PAB) and hemoglobin (Hb) levels were recorded. Subjective global assessment of nutritional status (SGA) was used to assess the nutritional status of patients and calculate the incidence of malnutrition.

Results

Of the 254 patients, 54 patients were accompanied by Hp infection (Hp infection group), and the Hp infection rate was 21.3%. No Hp infection was found in 200 patients (no Hp infection group). The levels of TNF-α, IL-6 and hs-CRP in patients with Hp infection were higher than those in patients without Hp infection. The levels of TSF, ALB, PAB and Hb in patients with Hp infection were lower than those in patients without Hp infection. The incidence of malnutrition in patients with Hp infection was higher than that in patients without Hp infection. The differences were statistically significant (all P<0.05).

Conclusions

Maintenance hemodialysis patients are accompanied by Hp infection. Compared with those infected with Hp, patients without Hp infection show less microinflammation and better nutritional status.

Key words: Maintenance hemodialysis, Helicobacter pylori, Microinflammation status, Nutritional status

Qi Wang. Effects of Helicobacter pylori infection on microinflammation and nutritional status in maintenance hemodialysis patients[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2021, 11(06): 276-279.

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References 15

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组别	例数	年龄（±s，岁）	性别（男性/女性，例）	基础疾病（例）				透析时间（±s，年）
组别	例数	年龄（±s，岁）	性别（男性/女性，例）	糖尿病肾病	慢性肾小球肾炎	高血压肾病	其他	透析时间（±s，年）
HP感染组	54	52.3±5.2	34/20	20	20	12	2	4.2±1.2
无HP感染组	200	52.4±5.7	111/89	73	71	46	10	4.3±1.4
检验值		t=-0.211	χ²=0.967	χ²=0.005	χ²=0.044	χ²=0.016	χ²=0.001	t=-0.379
P值		0.833	0.326	0.942	0.834	0.904	0.970	0.710

组别	例数	年龄（±s，岁）	性别（男性/女性，例）	基础疾病（例）				透析时间（±s，年）
组别	例数	年龄（±s，岁）	性别（男性/女性，例）	糖尿病肾病	慢性肾小球肾炎	高血压肾病	其他	透析时间（±s，年）
HP感染组	54	52.3±5.2	34/20	20	20	12	2	4.2±1.2
无HP感染组	200	52.4±5.7	111/89	73	71	46	10	4.3±1.4
检验值		t=-0.211	χ²=0.967	χ²=0.005	χ²=0.044	χ²=0.016	χ²=0.001	t=-0.379
P值		0.833	0.326	0.942	0.834	0.904	0.970	0.710

组别	例数	TNF-α（U/ml）	IL-6（pg/ml）	hs-CRP（mg/L）
HP感染组	54	104.2±6.3	16.2±4.1	20.2±0.3
无HP感染组	200	84.3±5.6	11.2±3.3	14.3±0.6
t值		22.788	9.366	73.586
P值		<0.05	<0.05	<0.05

组别	例数	TNF-α（U/ml）	IL-6（pg/ml）	hs-CRP（mg/L）
HP感染组	54	104.2±6.3	16.2±4.1	20.2±0.3
无HP感染组	200	84.3±5.6	11.2±3.3	14.3±0.6
t值		22.788	9.366	73.586
P值		<0.05	<0.05	<0.05

组别	例数	体重指数（kg/m²）	TSF（mm）	ALB（g/L）	PAB（mg/L）	Hb（g/L）
HP感染组	54	21.4±2.2	11.2±3.3	38.2±4.3	264.2±26.3	95.3±7.2
无HP感染组	200	22.3±5.5	16.2±4.1	45.3±3.6	291.2±22.6	103.3±9.4
t值		1.225	9.366	11.231	6.896	6.751
P值		>0.05	<0.05	<0.05	<0.05	<0.05

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