Value of three-dimensional arterial spin labeling combined with DCE-MRI in the diagnosis of postoperative recurrence and radiation brain necrosis of glioma

doi:10.3877/cma.j.issn.2095-2015.2023.04.016

Abstract

Abstract:

Objective

To analyze the clinical value of three-dimensional arterial spin labeling(3D-ASL)combined with dynamic contrast enhanced magnetic resonance imaging(DCE-MRI)in the diagnosis of recurrence of glioma and radiation brain necrosis.

Methods

Retrospective study was conducted on the clinical data of 60 patients with glioma who received postoperative adjuvant radiotherapy in Zhuozhou City Hospital from January 2019 to December 2021.The new abnormal enhancement lesions were found by routine MRI examination, and they were divided into postoperative recurrence group of glioma(n=38)and radiation brain necrosis group(n=22)after confirmed by secondary surgical pathology.The patients in both groups received MRI, 3D-ASL and DCE-MRI to obtain the quantitative parameters of 3D-ASL and DCE-MRI.The parameters of the two groups were compared and the clinical value of 3D-ASL combined with DCE-MRI in the diagnosis of postoperative recurrence and radiation brain necrosis of glioma was analyzed.

Results

The rCBF and Ktrans values of glioma recurrence group were higher than those of radiation brain necrosis group(P<0.05). The accuracy of 3D-ASL combined with DCE-MRI was higher than that of single examination(P<0.05). The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 3D-ASL combined with DCE-MRI were higher than those of single examination(P<0.05).

Conclusion

3D-ASL combined with DCE-MRI can be used clinically to distinguish the recurrence of brain glioma from radiation brain necrosis.The combined examination of the two has extremely high diagnostic value and can improve the diagnostic accuracy.

Key words: Glioma, Radiation brain necrosis, Three-dimensional arterial spin labeling, Dynamic contrast enhanced magnetic resonance imaging

Haitao Feng, Tao Xu, Wenyang Liu, Chen Sun, Shangchao Cao. Value of three-dimensional arterial spin labeling combined with DCE-MRI in the diagnosis of postoperative recurrence and radiation brain necrosis of glioma[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(04): 262-265.

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URL: https://zhxhbyyxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-2015.2023.04.016

https://zhxhbyyxzz.cma-cmc.com.cn/EN/Y2023/V13/I04/262

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References 20

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检查方法	灵敏度	特异度	准确度	阳性预测值	阴性预测值
3D-ASL	68.42(26/38)	63.64(14/22)	66.67(40/60)	76.47(26/34)	53.85(14/26)
DCE-MRI	73.68(28/38)	72.73(16/22)	73.33(44/60)	82.35(28/34)	61.54(16/26)
3D-ASL+DCE-MRI	92.11(35/38)	95.45(21/22)	93.33(56/60)	97.22(35/36)	87.50(21/24)
χ²值	6.866	6.729	13.371	6.526	6.958
P值	0.032	0.035	0.000	0.038	0.031

检查方法	灵敏度	特异度	准确度	阳性预测值	阴性预测值
3D-ASL	68.42(26/38)	63.64(14/22)	66.67(40/60)	76.47(26/34)	53.85(14/26)
DCE-MRI	73.68(28/38)	72.73(16/22)	73.33(44/60)	82.35(28/34)	61.54(16/26)
3D-ASL+DCE-MRI	92.11(35/38)	95.45(21/22)	93.33(56/60)	97.22(35/36)	87.50(21/24)
χ²值	6.866	6.729	13.371	6.526	6.958
P值	0.032	0.035	0.000	0.038	0.031

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