Correlation analysis between left ventricular function parameters and liver cirrhosis using non-invasive left ventricular pressure-strain cycle

doi:10.3877/cma.j.issn.2095-2015.2023.06.027

Abstract

Abstract:

Objective

To investigate the correlation between non-invasive left ventricular pressure-strain cycling(LVPSL)and Child-Pugh in patients with cirrhosis.

Methods

A total of 120 patients with cirrhosis and 40 healthy controls admitted to Dezhou Hospital, Qilu Hospital of Shandong University from January 1, 2020 to December 31, 2022 were prospectively included.According to the Child-Pugh score, patients with cirrhosis were divided into three subgroups: Child-Pugh class A group(A group, n=40), class B group(B group, n=40)and class C group(C group, n=40). Conventional echocardiographic parameters, left ventricular global longitudinal strain(LVGLS), left ventricular global work index(GWI), global constructive work(GCW), global wasted work(GWW), and global work efficiency(GWE)were collected.The correlation of conventional echocardiographic parameters, GLS, GWI, GCW, GWW and GWI with Child-Pugh score in cirrhotic patients was analyzed.

Results

Compared with the control group, conventional echocardiographic parameters in the cirrhosis group had no significant changes, but LVGLS, GWI, GCW and GWE were significantly decreased, while GWW was increased(P<0.01). Compared with the cirrhosis A group, LVGLS, GWI, GCW, and GWE in the B group were decreased, while GWW was increased(P<0.01). Compared with the cirrhosis group B, LVGLS, GWI, GCW and GWE in the C group were decreased, while GWW was increased(P<0.01). The Child-Pugh score of cirrhosis patients was negatively correlated with the absolute value of LVGLS, GWI, GCW, and GWE(r=-0.624, -0.586, -0647, -0.589), and positively correlated with GWW(r=0.724).

Conclusion

GWI, GCW, GWE and GWW based on the LVPSL technique can be used to quantitatively analyze myocardial work of different liver function grades.

Key words: Liver cirrhosis, Left ventricular pressure-strain cycle technique, Child-Pugh score, Myocardial work

Xiangyu Zhu, Jianmei Wang, Hui Zhang, Hongying Ye. Correlation analysis between left ventricular function parameters and liver cirrhosis using non-invasive left ventricular pressure-strain cycle[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 494-498.

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Figures/Tables 5

References 19

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组别	例数	男[例(%)]	女[例(%)]	年龄(岁，±s)	体重指数(kg/m²，±s)	心率(次/min，±s)	收缩压(mmHg，±s)	舒张压(mmHg，±s)
对照组	40	19(47.50)	21(52.50)	56.43±13.75	19.21±0.45	72.91±11.25	127.26±11.75	75.62±8.78
A组	40	18(45.00)	22(55.00)	54.83±12.58	19.34±0.53	69.75±9.87	124.75±10.48	72.34±8.24
B组	40	20(50.00)	20(50.00)	57.54±11.86	20.21±0.54	72.48±10.64	125.34±11.23	73.47±8.31
C组	40	19(47.50)	21(52.50)	56.78±12.37	19.87±0.47	75.24±12.37	123.19±9.87	77.48±9.04
F/χ²值		0.201	0.254	0.412	0.346	1.241	0.657	1.352
P值		0.978	0.936	0.736	0.824	0.246	0.464	0.137
组别	例数	肝硬化病因[例(%)]			合并症[例(%)]
组别	例数	病毒性	酒精性	其他	食管胃底静脉曲张	冠心病	胆石症	其他
对照组	40
A组	40	24(60.00)	13(32.50)	3(7.50)	11(27.50)	2(5.00)	3(7.50)	6(15.00)
B组	40	22(55.00)	16(40.00)	2(5.00)	9(22.50)	1(2.50)	2(5.00)	4(10.00)
C组	40	19(47.50)	17(42.50)	4(10.00)	10(25.00)	1(2.50)	2(5.00)	3(7.50)
F/χ²值		1.276	0.917	0.721	0.267	0.517	0.303	1.208
P值		0.528	0.632	0.697	0.875	0.772	0.859	0.547

组别	例数	男[例(%)]	女[例(%)]	年龄(岁，±s)	体重指数(kg/m²，±s)	心率(次/min，±s)	收缩压(mmHg，±s)	舒张压(mmHg，±s)
对照组	40	19(47.50)	21(52.50)	56.43±13.75	19.21±0.45	72.91±11.25	127.26±11.75	75.62±8.78
A组	40	18(45.00)	22(55.00)	54.83±12.58	19.34±0.53	69.75±9.87	124.75±10.48	72.34±8.24
B组	40	20(50.00)	20(50.00)	57.54±11.86	20.21±0.54	72.48±10.64	125.34±11.23	73.47±8.31
C组	40	19(47.50)	21(52.50)	56.78±12.37	19.87±0.47	75.24±12.37	123.19±9.87	77.48±9.04
F/χ²值		0.201	0.254	0.412	0.346	1.241	0.657	1.352
P值		0.978	0.936	0.736	0.824	0.246	0.464	0.137
组别	例数	肝硬化病因[例(%)]			合并症[例(%)]
组别	例数	病毒性	酒精性	其他	食管胃底静脉曲张	冠心病	胆石症	其他
对照组	40
A组	40	24(60.00)	13(32.50)	3(7.50)	11(27.50)	2(5.00)	3(7.50)	6(15.00)
B组	40	22(55.00)	16(40.00)	2(5.00)	9(22.50)	1(2.50)	2(5.00)	4(10.00)
C组	40	19(47.50)	17(42.50)	4(10.00)	10(25.00)	1(2.50)	2(5.00)	3(7.50)
F/χ²值		1.276	0.917	0.721	0.267	0.517	0.303	1.208
P值		0.528	0.632	0.697	0.875	0.772	0.859	0.547

组别	例数	LVDd(mm)	LAD(mm)	LVEF(%)	LVESV(mL)	LVEDV(mL)
对照组		46.38±3.09	29.83±2.61	63.04±2.54	36.87±6.49	104.78±14.83
A组	40	48.37±3.15	30.82±2.67	61.28±2.24	38.59±6.73	109.57±15.84
B组	40	47.48±3.26	31.26±2.74	62.31±2.48	34.25±5.78	112.46±16.57
C组	40	45.49±2.88	29.97±2.65	64.25±2.62	39.47±7.31	115.36±17.94
F值		1.256	0.785	0.587	1.254	1.875
P值		0.204	0.405	0.556	0.189	0.084

组别	例数	LVDd(mm)	LAD(mm)	LVEF(%)	LVESV(mL)	LVEDV(mL)
对照组		46.38±3.09	29.83±2.61	63.04±2.54	36.87±6.49	104.78±14.83
A组	40	48.37±3.15	30.82±2.67	61.28±2.24	38.59±6.73	109.57±15.84
B组	40	47.48±3.26	31.26±2.74	62.31±2.48	34.25±5.78	112.46±16.57
C组	40	45.49±2.88	29.97±2.65	64.25±2.62	39.47±7.31	115.36±17.94
F值		1.256	0.785	0.587	1.254	1.875
P值		0.204	0.405	0.556	0.189	0.084

组别	例数	LVGLS(%)	GWI(mmHg)	GCW(mmHg)	GWW(mmHg)	GWE(%)
对照组	40	－18.75±1.21	2017.03±265.38	1998.26±263.48	103.83±13.54	98.67±2.34
A组	40	－16.24±0.97^a	1768.34±246.27^a	1726.38±257.45^a	144.76±15.26^a	95.35±2.14^a
B组	40	－14.03±0.84^ab	1439.86±237.24^ab	1501.29±254.17^ab	165.47±16.89^ab	89.74±2.09^ab
C组	40	－11.39±0.64^abc	1121.04±224.28^abc	1139.26±242.31^abc	189.24±21.68^abc	84.53±1.98^abc
F值		58.342	30.654	25.647	15.248	13.274
P值		0.005	<0.001	<0.001	0.007	0.008

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