Relationship between RAB7A expression and clinicopathological features and liver metastasis in elderly patients with colorectal cancer

doi:10.3877/cma.j.issn.2095-2015.2025.03.003

Abstract

Abstract:

Objective

To analyze the relationship between RAB7A expression and clinicopathological features and liver metastasis of colorectal cancer (CRC) in elderly patients.

Methods

A total of 176 elderly CRC patients who underwent radical resection of CRC in Qinhuangdao Hospital of Peking University Third Hospital from January 2020 to December 2021 were retrospectively analyzed.Immunohistochemistry was used to detect the expression of RAB7A in cancer tissues, adjacent tissues and liver tissues of elderly CRC patients with liver metastasis.The clinicopathological characteristics of elderly CRC patients with different RAB7A expressions were analyzed.According to the status of liver metastasis within 3 years after prognosis, the elderly CRC patients were divided into the metastasis group (n=46) and the non-metastasis group (n=130), and the difference in RAB7A expression in cancer tissues between the two groups was analyzed.Receiver operating characteristic curve was used to analyze the predictive value of RAB7A expression in cancer tissues for the occurrence of liver metastasis in elderly CRC patients.Kaplan-Meier curve was used to analyze the effect of RAB7A expression on the occurrence of liver metastasis.

Results

The expression of RAB7A in CRC tissues of elderly patients was significantly higher than that in adjacent tissues (P<0.001).The expression of RAB7A in cancer tissues of elderly CRC patients was closely related to the depth of invasion and TNM stage (both P<0.05).RAB7A in cancer tissues of metastasis group was significantly higher than that in non-metastasis group (P<0.05).The expression of RAB7A in cancer tissues had a high predictive value for the occurrence of liver metastasis in elderly CRC patients (area under the curve=0.886, P<0.05).The Kaplan-Meier curve of liver metastasis in the RAB7A high expression group shifted to the left compared with the RAB7A low expression group (P<0.001),suggesting that the high expression of RAB7A in cancer tissues of elderly CRC patients increased the risk of liver metastasis.

Conclusion

RAB7A expression in cancer tissues of elderly CRC patients is significantly correlated with clinicopathological features.High expression of RAB7A increases the risk of liver metastasis and has a high predictive value for liver metastasis in elderly CRC patients, which can provide guidance for the treatment of clinical elderly CRC and the prevention and treatment of liver metastasis, and is expected to become a potential therapeutic target for liver metastasis in elderly CRC patients.

Key words: Colorectal cancer, Liver metastasis, RAB7A, Clinicopathological features, TNM staging, The elderly

Fantao Meng, Huilin Liu, Shuang Yang. Relationship between RAB7A expression and clinicopathological features and liver metastasis in elderly patients with colorectal cancer[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2025, 15(03): 205-209.

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URL: https://zhxhbyyxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-2015.2025.03.003

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References 29

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临床病理特征	例数	RAB7A 相对积分光密度值		χ ²	P
临床病理特征	例数	RAB7A高表达组(n=88)	RAB7A 低表达组(n=88)	χ ²	P
肿瘤部位
结肠	93	43(48.86)	50(56.82)	1.117	0.365
直肠	83	45(51.14)	38(43.18)
TNM 分期
I～Ⅱ期	113	47(53.41)	66(75.00)	8.925	0.004
Ⅲ期	63	41(46.59)	22(25.00)
浸润深度
T1～T2	131	55(62.50)	76(86.36)	13.166	0.001
T3～T4	45	33(37.50)	12(13.64)
淋巴转移
有	59	34(38.64)	25(28.41)	0.207	0.201
无	117	54(61.36)	63(71.59)

临床病理特征	例数	RAB7A 相对积分光密度值		χ ²	P
临床病理特征	例数	RAB7A高表达组(n=88)	RAB7A 低表达组(n=88)	χ ²	P
肿瘤部位
结肠	93	43(48.86)	50(56.82)	1.117	0.365
直肠	83	45(51.14)	38(43.18)
TNM 分期
I～Ⅱ期	113	47(53.41)	66(75.00)	8.925	0.004
Ⅲ期	63	41(46.59)	22(25.00)
浸润深度
T1～T2	131	55(62.50)	76(86.36)	13.166	0.001
T3～T4	45	33(37.50)	12(13.64)
淋巴转移
有	59	34(38.64)	25(28.41)	0.207	0.201
无	117	54(61.36)	63(71.59)

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