Study on the effect of Jianpi Huashi Decoction on chronic non-atrophic gastritis associated with Helicobacter pylori in spleen and stomach dampness-heat type

doi:10.3877/cma.j.issn.2095-2015.2025.06.008

Abstract

Abstract:

Objective

To investigate the clinical effect of Jianpi Huashi Decoction on chronic non-atrophic gastritis (CNG) associated with spleen and stomach dampness-heat type Helicobacter pylori (Hp).

Methods

A total of 120 patients with spleen and stomach damp-heat type HP-related CNG admitted to Weinan Central Hospital from January 2021 to December 2024 were selected as the study objects, and were divided into control group (n=60) and observation group (n=60) according to different treatment methods. The control group was treated with standard quadruple therapy, and the observation group was treated with Jianpi Huashi Decoction on the basis of the control group, and the course of treatment in both groups was 2 weeks. The clinical efficacy, inflammatory factors [interleukin (IL)-2, IL-6, tumor necrosis factor-α (TNF-α)], immune function indexes, pepsinogen (PG)Ⅰ, PGⅡ, traditional Chinese medicine syndrome score and occurrence of adverse reactions were compared between the two groups.

Results

The clinical total effective rate, CD₃⁺, CD₄⁺, CD₄⁺/CD₈⁺, PGI and PGⅡ levels in the observation group were higher than those in the control group after 2 weeks of treatment, and the levels of IL-2, IL-6, TNF-α, CD₈⁺ and traditional Chinese medicine syndrome score in the observation group were lower than those in the control group (P<0.05). There were no obvious adverse reactions in the two groups during treatment.

Conclusion

Jianpi Huashi Decoction has significant therapeutic effect on spleen and stomach dampness-heat type Hp-related CNG, which can effectively improve the symptoms of patients, increase the level of PG and reduce the level of serum inflammatory factors.

Key words: Chronic non-atrophic gastritis, Helicobacter pylori, Dampness-heat syndrome of spleen and stomach, Jianpi Huashi Decoction, Curative effect

Pengjuan Li, Hongge Li, Qinjun Zhang. Study on the effect of Jianpi Huashi Decoction on chronic non-atrophic gastritis associated with Helicobacter pylori in spleen and stomach dampness-heat type[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2025, 15(06): 599-603.

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References 24

[1]	张泰, 张北华, 马祥雪, 等. 慢性萎缩性胃炎炎-癌转化中医病机探析[J]. 中华中医药杂志, 2022, 37(11): 6414-6417.
[2]	陈艺楠, 纪海静, 白雪松, 等. Hp阳性慢性萎缩性胃炎中医药治疗研究进展[J]. 辽宁中医药大学学报, 2023, 25(1): 95-98.
[3]	Yang L, Liu X, Zhu J, et al. Progress in traditional Chinese medicine against chronic gastritis: From chronic non-atrophic gastritis to gastric precancerous lesions[J]. Heliyon, 2023, 9(6): 16764.
[4]	周泽华, 梁琨, 崔波, 等. 中药干预幽门螺杆菌阴性慢性萎缩性胃炎相关信号通路研究进展[J]. 中华中医药学刊, 2024, 42(5): 82-88.
[5]	罗慧, 唐梅文, 农复香, 等. 中医药防治慢性萎缩性胃炎癌变作用机制研究进展[J]. 陕西中医, 2023, 44(2): 267-270.
[6]	孙可昕, 裘生梁. 健脾化湿汤对慢性萎缩性胃炎患者临床症状、胃黏膜病理程度及胃功能指标的影响[J]. 中外医学研究, 2024, 22(20): 13-17.
[7]	中华医学会消化病学分会, 中华医学会消化病学分会消化系统肿瘤协作组, 房静远. 中国慢性胃炎诊治指南(2022年,上海)[J]. 胃肠病学, 2023, 28(3): 149-180.
[8]	中华中医药学会脾胃病分会, 唐旭东, 杨倩. 慢性胃炎中医诊疗专家共识(2023)[J]. 中华中医药杂志, 2023, 38(12): 5904-5911.
[9]	中华人民共和国卫生部. 中药新药临床研究指导原则(第一辑)[S]. 北京: 中国医药科技出版社, 2002: 153.
[10]	Si YT, Xiong XS, Wang JT, et al. Identification of chronic non-atrophic gastritis and intestinal metaplasia stages in the Correa's cascade through machine learning analyses of SERS spectral signature of non-invasively-collected human gastric fluid samples[J]. Biosens Bioelectron, 2024 15(262): 116530.
[11]	Luo J, Cao S, Ding N, et al. A deep learning method to assist with chronic atrophic gastritis diagnosis using white light images[J]. Dig Liver Dis, 2022, 54(11): 1513-1519.
[12]	索卓群, 李慧臻, 马佳乐, 等. 中医治疗慢性萎缩性胃炎的实验机制研究进展[J]. 中国中西医结合消化杂志, 2024, 32(7): 627-631.
[13]	赵晓琳, 诸葛丽, 马尚清, 等. 252例慢性萎缩性胃炎中医证候分布规律及其病理相关性研究[J]. 中华中医药杂志, 2022, 37(12): 7405-7408.
[14]	符常军, 江小鸽, 徐逸霖. 健脾化湿汤联合西药对中度活动期克罗恩病患者炎症活动指标的影响[J]. 四川中医, 2024, 42(5): 86-88.
[15]	石慧青, 张睿领, 王晓川, 等. 清热化湿通阳汤联合温针灸治疗慢性萎缩性胃炎脾胃湿热证的疗效及对生化指标的影响[J]. 四川中医, 2024, 42(9): 127-131.
[16]	易文全, 郝卫刚, 刘睿, 等. 血清胃蛋白酶原Ⅰ、Ⅱ及胃泌素17检测对慢性萎缩性胃炎的诊断价值[J]. 西部医学, 2022, 34(7): 1021-1025.
[17]	王春红. 连朴饮加减治疗脾胃湿热型慢性萎缩性胃炎临床研究[J]. 四川中医, 2021, 39(1): 90-93.
[18]	石敏益, 毛慧萍, 金辉, 等. 幽门螺杆菌感染合并消化性溃疡患儿血清炎性因子水平变化及与消化性溃疡的相关性分析[J]. 中国妇幼保健, 2023, 38(22): 4381-4384.
[19]	杨卫东, 周威, 向洪涛. 慢性萎缩性胃炎患者幽门螺杆菌感染与炎性细胞因子及病理特征的关系[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(5): 459-464.
[20]	厉志莲, 汪艳. 半夏莪术消痞汤治疗脾胃湿热型慢性非萎缩性胃炎临床研究及对胃肠激素水平的影响[J]. 辽宁中医杂志, 2023, 50(11): 163-166.
[21]	麦联任, 曾微微, 张清, 等. 清热化湿通阳汤辅助治疗慢性萎缩性胃炎脾胃湿热证的疗效及对生化指标的影响[J]. 四川中医, 2023, 41(5): 124-127.
[22]	索卓群, 李慧臻, 马佳乐, 等. 中医治疗慢性萎缩性胃炎的实验机制研究进展[J]. 中国中西医结合消化杂志, 2024, 32(7): 627-631.
[23]	曾静, 李明, 王雄, 等. 幽门螺杆菌感染慢性萎缩性胃炎患者中医辨证分型特点与癌前病变风险的关系[J]. 四川中医, 2022, 40(3): 60-63.
[24]	干晓花, 袁成业. 健脾清热化湿汤对脾胃湿热型慢性萎缩性胃炎患者中医症候积分、萎缩评分及PGI、PGII的影响[J]. 四川中医, 2021, 39(12): 109-112.

组别	例数	显效(例)	有效(例)	无效(例)	总有效率(%)
观察组	60	30	22	3	95.00
对照组	60	22	18	10	83.33

组别	例数	显效(例)	有效(例)	无效(例)	总有效率(%)
观察组	60	30	22	3	95.00
对照组	60	22	18	10	83.33

组别	例数	白细胞介素-2		白细胞介素-6		肿瘤坏死因子-α
组别	例数	治疗前	治疗2周后	治疗前	治疗2周后	治疗前	治疗2周后
观察组	60	22.31±3.24	11.15±2.26^*	50.63±5.20	34.95±3.33^*	5.18±0.59	2.10±0.44^*
对照组	60	22.29±3.18	15.63±2.68^*	50.55±5.12	41.90±4.35^*	5.20±0.46	2.89±0.48^*
t值		1.740	9.899	0.085	9.827	0.035	9.398
P值		0.084	0.000	0.932	0.000	0.972	0.000

组别	例数	白细胞介素-2		白细胞介素-6		肿瘤坏死因子-α
组别	例数	治疗前	治疗2周后	治疗前	治疗2周后	治疗前	治疗2周后
观察组	60	22.31±3.24	11.15±2.26^*	50.63±5.20	34.95±3.33^*	5.18±0.59	2.10±0.44^*
对照组	60	22.29±3.18	15.63±2.68^*	50.55±5.12	41.90±4.35^*	5.20±0.46	2.89±0.48^*
t值		1.740	9.899	0.085	9.827	0.035	9.398
P值		0.084	0.000	0.932	0.000	0.972	0.000

组别	例数	CD₃⁺(%)		CD₄⁺(%)		CD₈⁺(%)		CD₄⁺/CD₈⁺
组别	例数	治疗前	治疗2周后	治疗前	治疗2周后	治疗前	治疗2周后	治疗前	治疗2周后
观察组	60	27.28±3.07	40.14±4.16^*	37.25±4.03	48.61±5.83^*	27.68±2.79	20.64±2.03^*	1.41±0.20	2.15±0.43^*
对照组	60	27.35±2.86	34.13±3.37^*	37.12±4.11	41.32±5.04^*	27.73±3.02	22.41±2.12^*	1.45±0.14	1.85±0.30^*
t值		0.129	8.695	0.192	7.327	0.094	4.671	1.269	4.432
P值		0.897	0.000	0.848	0.000	0.925	0.000	0.207	0.000

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