Effectiveness of pronase and premedication with dimethylpolysiloxane for visualization of the mucosa during gastroscopy

doi:10.3877/cma.j.issn.2095-2015.2019.02.004

Abstract

Abstract:

Objective

To assess the efficacies of dimethylpolysiloxane plus pronase and dimethylpolysiloxane plus chymotrypsin for visualization of the mucosa during gastroscopy.

Methods

A total of 78 patients taken gastroscopy in Department of Endoscopy, Qianfoshan Hospital of Shandong Province were selected in January 2018.All the patients were randomly and double-blindly divided into two groups equally.The patients in group A(pronase group)received the solution of 5 g dimethylpolysiloxane, 20 000 U pronase, 1 g sodium bicarbonate and 50 ml warm water.The patients in group B(chymotrypsin group)received the solution of 5 g dimethylpolysiloxane, 4 000 U chymotrypsin, 1 g sodium bicarbonate and 50 ml warm water.The vision clarity of the two groups was contrastively analyzed.

Results

The antrum visibility, gastric body visibility, fundus visibility and the total visibility of group A were significantly higher than those of group B(antrum: 1.7±1.0 vs.1.2±0.5; gastric body: 2.6±0.8 vs.2.1±0.8; fundus: 1.9±0.8 vs.1.5±0.7; the total visibility: 6.2±2.1 vs.4.7±1.6), with statistically significant differences(all P<0.05).

Conclusion

Combined application of pronase plus dimethylpolysiloxane before gastroscopy significantly improves endoscopic visualization.And the effect is better than chymotrypsin plus dimethylpolysiloxane.

Key words: Pronase, Dimethylpolysiloxane, Gastroscopy, visualization

Haiyan Dong, Qiuping Pang, Shufen Su, Yan Zhang, Yan Lu, Xinyong Jia. Effectiveness of pronase and premedication with dimethylpolysiloxane for visualization of the mucosa during gastroscopy[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2019, 09(02): 65-67.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhxhbyyxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-2015.2019.02.004

https://zhxhbyyxzz.cma-cmc.com.cn/EN/Y2019/V09/I02/65

Figures/Tables 1

References 20

1	梁丽明，陈秀梅，张端．链霉蛋白酶对上消化道内镜检查胃内清晰度的效果观察[J]．吉林医学，2015，4(36):2083-2084.
2	孙昕，王青．西甲硅油在麻醉胃镜检查中的祛泡作用[J]．中华消化内镜杂志，2011，28(10):578-579.
3	Cha JM，Won KY，Chung IK，et al.Effect of pronase premedication on nallow-band imaging endoscopy in patients with precancerous conditions of stomach[J]．Dig Dis Sci，2014，59(11):2735-2741.
4	刘晓玲，韩杨，吴桂新，等．二甲硅油散在上消化道内镜诊治中的应用[J]．中国内镜杂志，2016，6(22):44-46.
5	倪倩雯，张毅，瞿春莹，等．西甲硅油联合链霉蛋白酶在胃镜检查中的应用[J]．胃肠病学和肝病学杂志，2013，22(7):660-663.
6	Petersen BT.Quality assurance for endoscopists[J]．Best Pract Res Clin Gastroenterol，2011，25(3):349-360.
7	Kwan V，Devière J．Endoscopy essentials：preparation，sedation，and surveillance[J]．Endoscopy，2008，40(1):65-70.
8	Cohen J，Safdi MA，Deal SE，et al.Quality indicators for esophagogastroduodenoscopy[J]．Am J Gastroenterol，2006，101(4):886-891.
9	Choi IJ.Gastric preparation for upper endoscopy[J]．Clin Endosc，2012，45(2):113-114.
10	王东，方军，厉有名，等．链霉蛋白酶提高胃镜检查图像可见度的前瞻性、多中心、双盲、随机对照临床研究[J]．中华消化内镜杂志，2013，30(11):604-607.
11	Chang CC，Chen SH，Lin CP，et al.Premedication with pronase or Naeetylcysteine improves visibility during gastroendoscopy：anendoscopist-blinded，prospective，andomized study[J]．World J Gastroenterol，2007，13(3):444-447.
12	武育卫，冯霞，彭贵勇，等．二甲硅油散在上消化道内镜检查中的作用[J]．中华消化内镜杂志，2009，26(2):95-96.
13	Tongprasert S，Sobhonslidsuk A，Rattanasiri S．Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation[J]．World J Gastroenterol，2009，15(24):3032-3037.
14	Woo JG，Kim TO，Kim HJ，et al.Determination of the optimal time for premedication with pmnase，dimethylpolysiloxane，and sodium bicarbonate for upper gastrointestinal endoscopy[J]．J Clin Gastroenterol，2013，47(5):389-392.
15	Lee GJ，Park SJ，Kim SJ，et al.Effectiveness of Premedication with Pronase for Visualization of the Mucosa during Endoscopy：A Randomized，Controlled Trial[J]．Clin Endosc，2012，45(2):161-164.
16	Sakai N，Tatsuta M，Iishi H，et al.Pre-medication with pronase reduces artefacts during endoscopic ultrasonography[J]．Aliment Pharmacol Ther，2003，18(3):327-332.
17	Capelle LG，Haringsma J，de Vries AC，et al.Narrow band imaging for the detection of gastric intestinal metaplasia and dysplasia during surveillance endoscopy[J]．Dig Dis Sci，2010，55:3442-3448.
18	陈新波，丰义宽，初国艳．胃镜术前准备研究进展[J]．中华消化内镜杂志.2016，32(2):133-135.
19	李静娴，侯俊，路海云，等．西甲硅油联合糜蛋白酶对提高胃镜检查祛泡效果的影响[J]．实用医学杂志，2014，30(20):3342-3344.
20	赵艳春，吴云林，左利平．西甲硅油联合糜蛋白酶溶液作胃镜检查术前准备的临床观察[J]．胃肠病学和肝病学杂志，2010，19(11):1019-1021.

组别	例数	男/女(例)	年龄(岁)	胃窦可见度(分)	胃体可见度(分)	胃底可见度(分)	总可见度(分)
链霉蛋白酶组	39	15/24	60.0±12.6	1.7±1.0	2.6±0.8	1.9±0.8	6.2±2.1
糜蛋白酶组	39	18/21	55.4±10.2	1.2±0.5	2.1±0.8	1.5±0.7	4.7±1.6
P值	?	0.647	0.081	0.015	0.004	0.007	0.001

组别	例数	男/女(例)	年龄(岁)	胃窦可见度(分)	胃体可见度(分)	胃底可见度(分)	总可见度(分)
链霉蛋白酶组	39	15/24	60.0±12.6	1.7±1.0	2.6±0.8	1.9±0.8	6.2±2.1
糜蛋白酶组	39	18/21	55.4±10.2	1.2±0.5	2.1±0.8	1.5±0.7	4.7±1.6
P值	?	0.647	0.081	0.015	0.004	0.007	0.001

[1]	Falan Tian, Jianzhong Chen, Zhuoma Zaxi, Dinggang Yu. Application of three-dimensional visualization technology in the treatment of complex hepatic echinococcosis [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(04): 257-261.
[2]	Song Liu, Qiongyuan Hu, Xiaofeng Lu, Wenxian Guan. Current situation and prospect of indocyanine green for surgical nerve imaging [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(02): 226-229.
[3]	Puliang Qi, Qingshan Tian, Lina Ma, Caixia Li, Ajid. Retrospective study of modified right hemihepatectomy for hepatocellular carcinoma guided by ICG tracer and 3D visualization technique [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(02): 162-166.
[4]	Bin Wang, Jing Wang, Zansheng Huang, Ping Wang, Chuangye Wang, Shuoxin Zhang, Heng Qin, Xiaorong Sun, Hongmei Wu, Jin Hu, Yu Yang, Mingzhou Zhang, Li Li, Zhi Xu. Application of lung ultrasound visualization bronchoalveolar lavage in the diagnosis of peripheral lung lesions [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(04): 466-470.
[5]	Lingzhan Meng, Hu Li, Peng Yu, Yanbin Yu, Li Cao, Wei Zhai, Yuan Gao, Yanling Shao, Jin Yan, Zhenyu Zhu. Application of ICG fluorescence staining in laparoscopic anatomical hepatectomy for primary liver cancer [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(05): 557-561.
[6]	Xudong Gao, Xiaoming Wang, Jiangming Chen, Shihang Xi, Xuan Pan. Three-dimensional classification of splenic artery in splenic hilum based on 3D visualization [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(04): 434-439.
[7]	Muertizha Mamutijiang, Yongxin Wang, Axier Aximujiang, Yanwen Jiang, Hu Qin. Multimodality fusion and three-dimensional reconstruction technology in surgical treatment of eloquent area lesions [J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(05): 302-307.
[8]	Zehui Huang, Jiexian Liang, Wei Zeng. Application of dexmedetomidine combined with esketamine in painless gastroscopy in children [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 510-513.
[9]	Mengzhen Liu. Effect of psychological counseling on emotion and success rate of patients undergoing electronic gastroscopy for the first time [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(05): 317-319.
[10]	Shifeng Gu, Lizi Zhang, Jingying Liang, Lili Du, Wen Sun, Dunjin Chen. Hot spots of placenta accreta spectrum disorders research in China from 2011 to 2021: a visualized analysis based on CiteSpace [J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2023, 12(03): 159-166.
[11]	Bo Zhang, Yi Yao, Wengang Zhang, Ningli Chai, Enqiang Linghu. Peroral cholangioscopy treatment of biliary and pancreatic disease: How super minimally invasive surgery have changed ERCP [J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2023, 10(04): 264-266.
[12]	Ziang Gao, Tianjiao Duan, Yuyong Tan, Deliang Liu, Tianying Duan. Bibliometric-based visualized analysis of research status and global trends of digestive endoscopic tunnel technique [J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2023, 10(03): 159-166.
[13]	Miao Lin, Shaoyuan Zhang, Mingxiang Feng, Lijie Tan, Jianyong Ding. International and domestic research advances of thymoma with visualized and evidence-based analysis of published papers [J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2023, 10(04): 213-223.
[14]	Hongling La, Yugeng Li, Guiping Xu, Tao Su. Effects of conscious sedation with dexmedetomidine and sufentanil in obese patients gastroscopy [J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2023, 10(02): 77-81.
[15]	Zhi Wang, Maimaitiaili, Huiling Li, Aikebair, Yiliang Li, Xiuli Deng, Kelimu·Abudureyimu. Clinical evaluation of laparoscopy combined with gastroscopy in the treatment of esophageal hiatal hernia with supraphrenic esophageal diverticulum [J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2022, 09(04): 196-198.

Please choose a citation manager

Content to export