Effectiveness of pronase and premedication with dimethylpolysiloxane for visualization of the mucosa during gastroscopy

doi:10.3877/cma.j.issn.2095-2015.2019.02.004

Abstract

Abstract:

Objective

To assess the efficacies of dimethylpolysiloxane plus pronase and dimethylpolysiloxane plus chymotrypsin for visualization of the mucosa during gastroscopy.

Methods

A total of 78 patients taken gastroscopy in Department of Endoscopy, Qianfoshan Hospital of Shandong Province were selected in January 2018.All the patients were randomly and double-blindly divided into two groups equally.The patients in group A(pronase group)received the solution of 5 g dimethylpolysiloxane, 20 000 U pronase, 1 g sodium bicarbonate and 50 ml warm water.The patients in group B(chymotrypsin group)received the solution of 5 g dimethylpolysiloxane, 4 000 U chymotrypsin, 1 g sodium bicarbonate and 50 ml warm water.The vision clarity of the two groups was contrastively analyzed.

Results

The antrum visibility, gastric body visibility, fundus visibility and the total visibility of group A were significantly higher than those of group B(antrum: 1.7±1.0 vs.1.2±0.5; gastric body: 2.6±0.8 vs.2.1±0.8; fundus: 1.9±0.8 vs.1.5±0.7; the total visibility: 6.2±2.1 vs.4.7±1.6), with statistically significant differences(all P<0.05).

Conclusion

Combined application of pronase plus dimethylpolysiloxane before gastroscopy significantly improves endoscopic visualization.And the effect is better than chymotrypsin plus dimethylpolysiloxane.

Key words: Pronase, Dimethylpolysiloxane, Gastroscopy, visualization

Haiyan Dong, Qiuping Pang, Shufen Su, Yan Zhang, Yan Lu, Xinyong Jia. Effectiveness of pronase and premedication with dimethylpolysiloxane for visualization of the mucosa during gastroscopy[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2019, 09(02): 65-67.

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References 20

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组别	例数	男/女(例)	年龄(岁)	胃窦可见度(分)	胃体可见度(分)	胃底可见度(分)	总可见度(分)
链霉蛋白酶组	39	15/24	60.0±12.6	1.7±1.0	2.6±0.8	1.9±0.8	6.2±2.1
糜蛋白酶组	39	18/21	55.4±10.2	1.2±0.5	2.1±0.8	1.5±0.7	4.7±1.6
P值	?	0.647	0.081	0.015	0.004	0.007	0.001

组别	例数	男/女(例)	年龄(岁)	胃窦可见度(分)	胃体可见度(分)	胃底可见度(分)	总可见度(分)
链霉蛋白酶组	39	15/24	60.0±12.6	1.7±1.0	2.6±0.8	1.9±0.8	6.2±2.1
糜蛋白酶组	39	18/21	55.4±10.2	1.2±0.5	2.1±0.8	1.5±0.7	4.7±1.6
P值	?	0.647	0.081	0.015	0.004	0.007	0.001

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