Study on the role of circRNA in gastric carcinogenesis

doi:10.3877/cma.j.issn.2095-2015.2020.02.010

Abstract

Abstract:

Different from linear RNA, a covalent closed structure lacking 5′ cap and 3′ polyA tail is found in cells.Because of its annular characteristics, it has higher stability and conservatism.This kind of RNA is called circular RNA(circRNA). It plays a regulatory role at the transcriptional and post-transcriptional levels and has an impact on the occurrence and development of tumors.This paper focuses on the summary of the specific expression and biological function of circRNAs, and discusses the potential clinical application as a biomarker or target for the diagnosis, treatment and prognosis of gastric cancer.

Key words: Gastric cancer, CircRNA

Xinrui Zhang, Guodong Rong, Hong Zhao, Ting Xu, Yan Zhang, Peijun Huang, Fang Wang, Lei Wu. Study on the role of circRNA in gastric carcinogenesis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2020, 10(02): 84-88.

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Figures/Tables 2

References 60

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CircRNAs	位置	表达	作用机制
circ_SPECC1^[24]	组织	下调	竞争结合miR-526b，进而影响KDM4A/YAP1的表达；过表达抑制胃癌细胞增殖与侵袭
circYAP1^[25]	组织	下调	竞争结合miR-367-5p，进而影响p27 Kip1的表达；过表达能抑制胃癌细胞增殖与侵袭
circLARP4^[26]	组织	下调	竞争结合miR-424，进而影响LATS1的表达；过表达能抑制胃癌细胞增殖与侵袭
circZFR^[27]	组织	下调	竞争结合miR-107/miR-130a，进而影响PTEN的表达；过表达能抑制胃癌细胞增殖与促进凋亡
circPSMC3^[28]	组织/血浆	下调	竞争结合miR-296-5p，进而影响PTEN的表达；过表达能抑制胃癌细胞增殖
hsa_circ_0006848^[29]	组织/血浆	下调	竞争结合miR-329-5p
hsa_circ_0000993^[30]	组织	下调	竞争结合miR-214-5p；过表达抑制胃癌细胞增殖、侵袭与转移
has_circ_0001461^[31]	组织	下调	竞争结合miR-548g，进而影响RUNX1的表达；过表达能抑制胃癌细胞增殖、侵袭与转移
hsa_circ_0027599^[32]	组织	下调	竞争结合miR-101，进而影响PHLDA1的表达；过表达能抑制胃癌细胞增殖与转移
hsa_circ_100269^[33]	组织	下调	竞争结合miR-30；过表达抑制胃癌细胞增殖
ciRS-7^[34]	组织	上调	竞争结合miR-7，进而影响PTEN/PI3K/AKT通路
circ-DONSON^[35]	组织	上调	位于细胞核，能够将核重塑因子复合体NURF招募到SOX4的启动子区域，引起转录激活；干扰表达能抑制胃癌细胞增殖、迁移与侵袭
circRNA_001569^[36]	组织	上调	竞争结合miR-145，进而影响NR4A2的表达；干扰表达能抑制胃癌细胞凋亡
circSFMBT2^[37]	组织	上调	竞争结合miR-182-5p，进而影响CREB1的表达；干扰表达能抑制胃癌细胞增殖
circHIPK3^[38]	组织	上调	竞争结合miR-124/miR-29b
circNF1^[39]	组织	上调	竞争结合miR-16，进而影响MAP7/AKT3的表达；干扰表达能抑制胃癌细胞增殖与迁移
circPVT1^[40]	组织	上调	竞争结合miR-125；干扰表达能抑制胃癌细胞增殖
circHECTD1^[41]	组织	上调	竞争结合miR-1256，进而影响USP5的表达；干扰表达能抑制胃癌细胞增殖、迁移与侵袭
circPDSS1^[42]	组织	上调	竞争结合miR-186-5p，进而影响NEK2的表达；干扰表达能抑制胃癌细胞增殖
hsa_circ_0008549^[43]	组织	上调	竞争结合miR-136-5p，进而影响WNT2的表达；干扰表达能抑制胃癌细胞增殖、迁移与侵袭
hsa_circ_006100^[44]	组织	上调	竞争结合miR-195，进而影响GPRC5A的表达；干扰表达能抑制胃癌细胞增殖
hsa_circ_0092303^[45]	组织	上调	竞争结合m iR-331-3p，进而影响TGFBR1的表达；干扰表达能抑制胃癌细胞增殖、迁移与侵袭

CircRNAs	位置	表达	作用机制
circ_SPECC1^[24]	组织	下调	竞争结合miR-526b，进而影响KDM4A/YAP1的表达；过表达抑制胃癌细胞增殖与侵袭
circYAP1^[25]	组织	下调	竞争结合miR-367-5p，进而影响p27 Kip1的表达；过表达能抑制胃癌细胞增殖与侵袭
circLARP4^[26]	组织	下调	竞争结合miR-424，进而影响LATS1的表达；过表达能抑制胃癌细胞增殖与侵袭
circZFR^[27]	组织	下调	竞争结合miR-107/miR-130a，进而影响PTEN的表达；过表达能抑制胃癌细胞增殖与促进凋亡
circPSMC3^[28]	组织/血浆	下调	竞争结合miR-296-5p，进而影响PTEN的表达；过表达能抑制胃癌细胞增殖
hsa_circ_0006848^[29]	组织/血浆	下调	竞争结合miR-329-5p
hsa_circ_0000993^[30]	组织	下调	竞争结合miR-214-5p；过表达抑制胃癌细胞增殖、侵袭与转移
has_circ_0001461^[31]	组织	下调	竞争结合miR-548g，进而影响RUNX1的表达；过表达能抑制胃癌细胞增殖、侵袭与转移
hsa_circ_0027599^[32]	组织	下调	竞争结合miR-101，进而影响PHLDA1的表达；过表达能抑制胃癌细胞增殖与转移
hsa_circ_100269^[33]	组织	下调	竞争结合miR-30；过表达抑制胃癌细胞增殖
ciRS-7^[34]	组织	上调	竞争结合miR-7，进而影响PTEN/PI3K/AKT通路
circ-DONSON^[35]	组织	上调	位于细胞核，能够将核重塑因子复合体NURF招募到SOX4的启动子区域，引起转录激活；干扰表达能抑制胃癌细胞增殖、迁移与侵袭
circRNA_001569^[36]	组织	上调	竞争结合miR-145，进而影响NR4A2的表达；干扰表达能抑制胃癌细胞凋亡
circSFMBT2^[37]	组织	上调	竞争结合miR-182-5p，进而影响CREB1的表达；干扰表达能抑制胃癌细胞增殖
circHIPK3^[38]	组织	上调	竞争结合miR-124/miR-29b
circNF1^[39]	组织	上调	竞争结合miR-16，进而影响MAP7/AKT3的表达；干扰表达能抑制胃癌细胞增殖与迁移
circPVT1^[40]	组织	上调	竞争结合miR-125；干扰表达能抑制胃癌细胞增殖
circHECTD1^[41]	组织	上调	竞争结合miR-1256，进而影响USP5的表达；干扰表达能抑制胃癌细胞增殖、迁移与侵袭
circPDSS1^[42]	组织	上调	竞争结合miR-186-5p，进而影响NEK2的表达；干扰表达能抑制胃癌细胞增殖
hsa_circ_0008549^[43]	组织	上调	竞争结合miR-136-5p，进而影响WNT2的表达；干扰表达能抑制胃癌细胞增殖、迁移与侵袭
hsa_circ_006100^[44]	组织	上调	竞争结合miR-195，进而影响GPRC5A的表达；干扰表达能抑制胃癌细胞增殖
hsa_circ_0092303^[45]	组织	上调	竞争结合m iR-331-3p，进而影响TGFBR1的表达；干扰表达能抑制胃癌细胞增殖、迁移与侵袭

CircRNAs	位置	表达	敏感度(%)	特异度(%)	AUC
circ-SFMBT2^[37]	组织	上调	80.56	63.89	0.7585
circ-KIAA1244^[46]	血浆	下调	77.42	68	0.7481
circPVRL3^[47]	组织	下调	90.3	56.4	0.7626
hsa_circ_0000181^[48]	组织	下调	53.9	85.2	0.756
?	血浆	下调	99.0	20.6	0.582
hsa_circ_0000190^[49]	组织	下调	72.1	68.3	0.75
?	血浆	下调	41.4	87.5	0.60
hsa_circ_0000520^[50]	组织	下调	53.57	85.71	0.6129
?	血浆	下调	82.35	84.44	0.8967
hsa_circ_0000745^[51]	血浆	下调	85.5	45	0.683
hsa_circ_0001649^[52]	组织	下调	71.1	81.6	0.834
hsa_circ_002059^[53]	组织/血浆	下调	81	62	0.73
hsa_circ_0003159^[54]	组织	下调	85.2	56.5	0.75
hsa_circ_0014717^[55]	组织	下调	59.38	81.25	0.696
hsa_circ_0074362^[56]	组织	下调	36.2	84.3	0.63
hsa_circ_0001895^[57]	组织	下调	67.8	85.7	0.792
hsa_circ_0006633^[58]	组织	下调	60	81	0.741
hsa_circ_0000467^[59]	血浆	上调	70.5	64.8	0.79
hsa_circ_0066444^[60]	组织	上调	70.75	68.87	0.7328

CircRNAs	位置	表达	敏感度(%)	特异度(%)	AUC
circ-SFMBT2^[37]	组织	上调	80.56	63.89	0.7585
circ-KIAA1244^[46]	血浆	下调	77.42	68	0.7481
circPVRL3^[47]	组织	下调	90.3	56.4	0.7626
hsa_circ_0000181^[48]	组织	下调	53.9	85.2	0.756
?	血浆	下调	99.0	20.6	0.582
hsa_circ_0000190^[49]	组织	下调	72.1	68.3	0.75
?	血浆	下调	41.4	87.5	0.60
hsa_circ_0000520^[50]	组织	下调	53.57	85.71	0.6129
?	血浆	下调	82.35	84.44	0.8967
hsa_circ_0000745^[51]	血浆	下调	85.5	45	0.683
hsa_circ_0001649^[52]	组织	下调	71.1	81.6	0.834
hsa_circ_002059^[53]	组织/血浆	下调	81	62	0.73
hsa_circ_0003159^[54]	组织	下调	85.2	56.5	0.75
hsa_circ_0014717^[55]	组织	下调	59.38	81.25	0.696
hsa_circ_0074362^[56]	组织	下调	36.2	84.3	0.63
hsa_circ_0001895^[57]	组织	下调	67.8	85.7	0.792
hsa_circ_0006633^[58]	组织	下调	60	81	0.741
hsa_circ_0000467^[59]	血浆	上调	70.5	64.8	0.79
hsa_circ_0066444^[60]	组织	上调	70.75	68.87	0.7328

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