Research progress of long non-coding RNA as a non-invasive marker in hepatocellular carcinoma

doi:10.3877/cma.j.issn.2095-2015.2020.03.004

Abstract

Abstract:

The early symptoms of hepatocellular carcinoma (HCC) are not obvious, the heterogeneity is strong and the degree of malignancy is very high. Currently, there is a lack of effective diagnosis and treatment methods, resulting in poor prognosis and high mortality. In recent years, it has been found that long non-coding RNA (lncRNA) can be used as a new tumor marker in the diagnosis of HCC. The lncRNAs in plasma, serum, exosomes, saliva and other body fluids includ SNHG1, HEIH, HULC, Linc00152, ZFAS1, Uc001ncr, Ax800134, LRB1, UCA1, D16366, ENSG00000258332.1, LINC00635, LncRNA-ATB, LINC00161, LncRNA-PCDH9-13:1 and others. The combination of lncRNA and AFP, lncRNA-related risk scoring system and exosomal competing endogenous RNA (ceRNA) biomarker panel can effectively improve the diagnostic and predictive efficiency of lncRNAs for HCC.

Key words: Hepatocellular carcinoma, Long non-coding RNAs, Noninvasive, Biomarkers

Xinran Lyu, Lili Cao. Research progress of long non-coding RNA as a non-invasive marker in hepatocellular carcinoma[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2020, 10(03): 109-114.

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