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Chinese Journal of Digestion and Medical Imageology(Electronic Edition) ›› 2022, Vol. 12 ›› Issue (06): 373-376. doi: 10.3877/cma.j.issn.2095-2015.2022.06.010

• Review • Previous Articles     Next Articles

Progress in clinical application of third space endoscopy

Peng Xu1, Zhi Wei2,()   

  1. 1. Department of Gastroenterology, Public Health Clinical Center of Shandong Province, Jinan 250098, China
    2. Department of Gastroenterology, Second People′s Hospital of Shandong Province, Jinan 250022, China
  • Received:2022-05-19 Online:2022-12-01 Published:2023-01-11
  • Contact: Zhi Wei

Abstract:

The third space endoscopy or intramural endoscopy is based on the principle that the deeper layers of the gastrointestinal tract can be accessed by tunneling in the submucosal space and maintaining the integrity of the overlying mucosa.The era of third space endoscopy started with peroral endoscopic myotomy for the treatment of achalasia, and has been expanded to treat various other gastrointestinal diseases.The technique is also currently used for treatment of refractory gastroparesis, Zenker′s diverticulum, resection of subepithelial tumors, early cancers of the gastrointestinal tract and Hirschsprung′s disease.These procedures are rapidly emerging as minimally invasive alternatives to conventional surgery, and have been proven to be safe and effective.This review focuses on the evolution and current applications of third space endoscopy in various gastrointestinal diseases.

Key words: Gastrointestinal diseases, Third space endoscopy, Peroral endoscopy myotomy, Application progress

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