To observe the efficacy of local anesthetic drugs applied during laparoscopic appendectomy(LA)on postoperative pain.

This study prospectively included 120 patients who underwent LA in our hospital from March 2020 to March 2023, and all patients were randomly divided into control group, lidocaine group, levobupivacaine group and ropivacaine group, with 30 patients in each group.The pain levels at 2 h, 6 h, 12 h, 24 h and 48 h after awakening from general anesthesia, characteristics and frequency of postoperative pain, quality of life scores(SF-36 scale)before and 48 h after surgery, and the incidence of adverse reactions at 48 h after surgery were compared among the four groups, respectively.

There were no significant differences in age, gender, BMI, ASA classification(gradeⅠandⅡ), anesthesia time, intraoperative bleeding and operative time among the four groups(P>0.05), but the time to first bed activity and hospital stay were reduced in the lidocaine, levobupivacaine and ropivacaine groups compared with the control group, with statistically significant differences(P<0.05). Compared with the control group, the VAS scores at 2, 6, 12, 24 and 48 h after surgery were reduced in the lidocaine, levobupivacaine and ropivacaine groups, but the VAS score was most significantly reduced in the levobupivacaine group, followed by the ropivacaine group, and finally the lidocaine group, with statistically significant differences(P<0.001). Compared with the control group, the lidocaine, levobupivacaine and ropivacaine groups had lower pain frequency and predominantly dull pain, with statistically significant differences(P<0.05). There was no statistically significant difference in the SF-36 scale scores for each dimension(somatic pain, health index, emotion and life satisfaction)among the four groups 48 h before surgery(P>0.05). The SF-36 scale scores for each dimension at 48 h after surgery were significantly higher than those before treatment(P<0.05), and after treatment, the scores for each dimension in the lidocaine, levobupivacaine and ropivacaine groups were higher than those in the control group, with the SF-36 scale scores in the levobupivacaine group being the most significantly elevated, followed by the ropivacaine group and finally the lidocaine group, with statistically significant differences(P<0.001). There was no statistically significant difference in the overall incidence of adverse reactions among the four groups within 48 h(P>0.05).

Local anesthetic drugs have a significant analgesic effect on patients with appendicitis after performing LA, and can effectively improve the quality of life of patients with appendicitis after LA.