Abstract:
Objective To investigate the effect of oral metformin on postoperative recurrence of type 2 diabetes mellitus with colorectal adenoma.
Methods Prospectively, 186 patients with type 2 diabetes mellitus with colorectal adenoma who underwent endoscopic mucosal resection(EMR)in Fengfeng General Hospital of North China Medical and Healthcare Group were included from June 2019 to June 2022, and finally 150 patients were enrolled and divided into the control group and the observation group by randomized alphabetical method, with 75 patients in each group.The patients in the control group were given conventional treatments such as nutritional support and insulin to control blood glucose after surgery; the patients in the observation group were treated with oral metformin on the basis of the control group.The clinical efficacy, serum inflammation index, recurrence and adverse reactions were compared between the two groups.
Results The treatment apparent rate 5 months after operation and total effective rate of the observation group were significantly higher than those of the control group(73.33% vs.36.00%、89.33% vs.60.00%, P<0.05). The levels of serum inflammation indexes of patients in the two groups were significantly lower compared with the preoperative period, and the C-reactive protein, interleukin-6 and interleukin-8 of the observation group were significantly lower than those of the control group [(4.21±0.23)mg/L vs.(5.13±0.11)mg/L, (4.92±2.57)pg/mL vs.(6.13±3.11)pg/mL, (42.14±2.52)pg/mL vs.(45.21±2.48)pg/mL, P<0.05]. In addition, the relapse rate in the observation group was significantly lower than that in the control group(21.00% vs.42.67%, P<0.05). Meanwhile, there was no statistically significant difference in the total incidence of adverse reactions during treatment between the two groups.
Conclusion Metformin can significantly inhibit postoperative recurrence of colorectal adenoma in patients with type 2 diabetes mellitus, and can further relieve inflammation with high safety.
Key words:
Type 2 diabetes mellitus,
Colorectal adenoma,
Endoscopic mucosal resection,
Metformin,
Recurrence rate,
Adverse effects
Zhengying Zhang, Yang Ju, Xiaoning Liu. Effect of oral metformin on postoperative recurrence of type 2 diabetes mellitus with colorectal adenoma[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 485-488.