To investigate effects of Yiqi Shengxue Decoction combined with tetralogy of viable bifidobacterium tablet on intestinal floras, gastrointestinal hormones, serum nuclear factor-κB (NF-κB) and interleukin 6 (IL-6) in patients with chronic gastric ulcer.

A total of 112 patients with chronic gastric ulcer admitted to Xi'an Traditional Chinese Medicine Hospital were enrolled as the research objects between April 2022 and April 2024. They were randomly divided into observation group (n=56) and control group (n=56). The control group was treated with routine Western medicine+ tetralogy of viable bifidobacterium tablets, while observation group was additionally treated with Yiqi Shengxue Decoction. Both groups were treated for 8 weeks. The total response rates after treatment, changes in diameter, area and coverage rate of ulcer, intestinal floras, gastrointestinal hormones (gastrin, motilin, cholecystokinin), serum NF-κB, IL-6 and vascular endothelial growth factor (VEGF) in the two groups were compared.

The response rate of treatment was higher in observation group than control group (92.86% vs. 78.57%, P<0.05). The diameter, area and coverage rate of ulcer were lower in observation group than control group (P<0.05). The counts of Enterococcus and Escherichia coli were lower in observation group than control group, while counts of Bifidobacterium and Lactobacillus were higher in observation group (P<0.05). Motilin level was higher in observation group than control group, while gastrin and cholecystokinin levels were lower in observation group (P<0.05). VEGF level was higher in observation group than control group, while NF-κB and IL-6 levels were lower in observation group (P<0.05).

Yiqi Shengxue Decoction combined with tetralogy of viable bifidobacterium tablets can significantly alleviate ulcers severity and inflammatory response in patients with chronic gastric ulcer, improve levels of gastrin and other gastrointestinal hormones, promote the recovery of gastrointestinal biological barrier and improve clinical curative effect.