To explore the clinical efficacy of the combination therapy of phenethylamine and rabeprazole in the treatment of ulcerative upper gastrointestinal bleeding and its impact on patients' oxidative stress response.

A total of 112 patients with ulcerative upper gastrointestinal bleeding admitted to our hospital from July 2022 to March 2025 were selected as the study subjects. According to the random number table method, they were divided into a control group of 56 patients treated with rabeprazole and an observation group of 56 patients treated with a combination of phenethylamine and rabeprazole, and the treatment course were all 5 days. The clinical efficacy, platelet function, coagulation function, oxidative stress response, and incidence of adverse reactions were compared between the two groups.

The clinical total effective rate of the observation group (94.64%) was higher than that of the control group (73.21%, P<0.05). Compared with before treatment, both groups showed an increase in mean platelet volume (MPV), platelet count (PLT), and maximal platelet aggregation rate (MAR) after 5 days of treatment (P<0.05); Compared with the control group, the observation group showed more significant increases in MPV, PLT, and MAR after 5 days of treatment (P<0.05). Compared with before treatment, after 5 days of treatment, both groups showed a decrease in prothrombin time (PT) and partial thromboplastin time (APTT), and an increase in fibrinogen (FIB) levels (P<0.05); Compared with the control group after 5 days of treatment, the observation group showed more significant shortening of APTT and PT, and more significant increase in FIB (P<0.05). Compared with before treatment, the levels of superoxide dismutase (SOD) increased in both groups after 5 days of treatment, while the levels of cortisol decreased (P<0.05); Compared with the control group after 5 days of treatment, the observation group showed a more significant increase in SOD levels and a more significant decrease in cortisol levels after 5 days of treatment (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups of patients (χ²=0.327, P=0.568).

The combination of phenethylamine and rabeprazole can effectively improve platelet function and coagulation function in patients with ulcerative upper gastrointestinal bleeding, reduce oxidative stress levels in the body, improve clinical efficacy, and has high safety.