Endoscopic iodine staining for clinical investigation of esophageal disease screening in Huai′an of Jiangsu Province with a survey of 1983 cases

doi:10.3877/cma.j.issn.2095-2015.2019.01.005

Abstract

Abstract:

Objective

To investigate the important clinical value of endoscopic iodine staining in endoscopic screening of esophageal early cancer in high incidence area of esophageal cancer.

Methods

Endoscopic esophageal cancer screening was performed on 1 983 patients aged 40-60 years in Wudun Town and Yanhe Town, Qingpu District, Huai′an City of Jiangsu Province.The color and morphology of esophageal mucosa were compared before and after iodine staining, and biopsy was performed on abnormal mucosa staining.

Results

A total of 835 lesions in 740 patients underwent esophageal biopsy, 273 were found before iodine staining(white light), and 562 were found after iodine staining.Among them, 5 cases of intramucosal carcinoma and 205 cases of dysplasia were found after iodine staining.The difference between the two groups was statistically significant(P<0.05), which indicated that the detection rate of esophageal cancer and precancerous lesions after iodine staining was significantly higher than that before staining.

Conclusion

Endoscopic iodine staining of esophageal mucosa can significantly improve the detection rate of esophageal cancer and precancerous lesions during screening.Because of its low price and simple operation, it is worthy of clinical application.

Key words: Esophageal cancer, Endoscopy, Iodine staining

Feng Liang, Xiao Qiao, Changcheng Wang, Chengyan Han, Bingyin Yang, Shiyan Yang, Shuqing Liu. Endoscopic iodine staining for clinical investigation of esophageal disease screening in Huai′an of Jiangsu Province with a survey of 1983 cases[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2019, 09(01): 17-21.

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References 14

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黏膜碘染分类	病理结果							合计
黏膜碘染分类	炎症	轻度不典型增生	中度不典型增生	重度不典型增生	黏膜内癌	黏膜下癌	浸润癌	合计
Ⅰ	3	33	24	9	5	1	5	80
Ⅱ	26	59	16	5	2	1	0	109
Ⅲ	459	143	43	1	0	0	0	646
合计	488	235	83	15	7	2	5	835

黏膜碘染分类	病理结果							合计
黏膜碘染分类	炎症	轻度不典型增生	中度不典型增生	重度不典型增生	黏膜内癌	黏膜下癌	浸润癌	合计
Ⅰ	3	33	24	9	5	1	5	80
Ⅱ	26	59	16	5	2	1	0	109
Ⅲ	459	143	43	1	0	0	0	646
合计	488	235	83	15	7	2	5	835

白光表现	病理结果							合计
白光表现	炎症	轻度不典型增生	中度不典型增生	重度不典型增生	黏膜内癌	黏膜下癌	浸润癌	合计
阴性	352	150	50	5	5	0	0	562
阳性	135	85	33	10	2	2	5	273
合计	488	235	83	15	7	2	5	835
内镜下阳性率(%)	27.7	36.2	39.8	66.7	28.6	100	100	32.7

白光表现	病理结果							合计
白光表现	炎症	轻度不典型增生	中度不典型增生	重度不典型增生	黏膜内癌	黏膜下癌	浸润癌	合计
阴性	352	150	50	5	5	0	0	562
阳性	135	85	33	10	2	2	5	273
合计	488	235	83	15	7	2	5	835
内镜下阳性率(%)	27.7	36.2	39.8	66.7	28.6	100	100	32.7

组别	内镜下阳性表现后病理活检(例)		诊断阳性率(%)
组别	阳性	阴性	诊断阳性率(%)
碘染色前	9	5	64.3
碘染色后	14	0	100
P值	?	?	0.041

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