Abstract:
Objective To systematically evaluate the efficacy and safety of somatostatin combined with ulinastatin in the treatment of gastrointestinal hemorrhage.
Methods CNKI, VIP, Wanfang, CBM database, PubMed, Cochrane Library, EMBase were searched to collect randomized controlled trials of somatostatin combined with ulinastatin in the treatment of gastrointestinal bleeding.Mete analysis was performed using Revman 5.3 software.
Results A total of 16 studies involving 1466 patients were included.The results showed that somatostatin combined with ulinastatin was better than somatostatin alone in the total effective rate(RR=1.24, 95% CI: 1.19-1.31, P<0.000 01), interleukin-2(SMD=1.10, 95% CI: 0.38-1.81, P=0.003), interleukin-6(SMD=-3.40, 95% CI: -4.69--2.12, P<0.000 01), interleukin-10(SMD=2.77, 95% CI: 1.66-3.87, P<0.000 01), tumor necrosis factor-α(SMD=-2.56, 95% CI: -3.26--1.87, P<0.000 01), hospitalization time(SMD=-1.75, 95% CI: -2.24--1.26, P<0.000 01)and gastrointestinal hemostasis time(SMD=-3.55, 95% CI: -4.11--2.99, P<0.000 01). There was no statistically significant difference in the incidence of adverse reactions between the two groups(SMD=0.79, 95% CI: 0.47-1.32, P=0.38), and both were lower.
Conclusion Somatostatin combined with ulinastatin in the treatment of gastrointestinal bleeding is safe and effective, but it needs more high-quality clinical trials to verify.
Key words:
Gastrointestinal bleeding,
Ulinastatin,
Somatostatin,
Meta analysis
Langhuan Zhou, Weiling Gong, Fuchun Sun, Song Song. Meta analysis of somatostatin combined with ulinastatin in the treatment of gastrointestinal bleeding[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(01): 26-32.