Current research and application status and prospect of 3D printing technology in gastrointestinal tumors

doi:10.3877/cma.j.issn.2095-2015.2025.05.023

Abstract

Abstract:

Three-dimensional (3D) printing technology has been applied in orthopedics, maxillofacial surgery, neurosurgery, cardiac surgery and other medical fields, which has become a research hotspot, but the research and application in the field of gastrointestinal tumors are still lacking in bulk literature reports. In this review, the clinical application and basic research status and prospect of 3D printing technology in the field of gastrointestinal tumors are summarized, and the problems existing in the process of research and application are preliminarily suggested.

Key words: Gastrointestinal tumor, Printing, three-dimensional, Digital medicine

Jinming Zhu. Current research and application status and prospect of 3D printing technology in gastrointestinal tumors[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2025, 15(05): 552-557.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhxhbyyxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-2015.2025.05.023

https://zhxhbyyxzz.cma-cmc.com.cn/EN/Y2025/V15/I05/552

References 47

[1]	Han B, Zheng R, Zeng H, et al. Cancer incidence and mortality in China, 2022[J]. J Natl Cancer Cent, 2024, 4(1): 47-53.
[2]	Agarwal P, Arora G, Panwar A, et al. Diverse Applications of Three- Dimensional Printing in Biomedical Engineering: A Review[J]. 3D Print Addit Manuf, 2023, 10(5): 1140-1163.
[3]	Habermann AC, Timmerman WR, Cohen SM, et al. Clinical applications of 3D printing in colorectal surgery: A systematic review[J]. Int J Colorectal Dis, 2024, 39(1): 127-143.
[4]	吴宸, 彭方兴, 罗亮, 等. 3D打印技术在复杂胃肠道肿瘤手术中的应用研究[J]. 中国医学装备, 2020, 17(3): 89-92.
[5]	Andersen BT, Stimec BV, Edwin B, et al. Re-interpreting mesenteric vascular anatomy on 3D virtual and/or physical models: positioning the middle colic artery bifurcation and its relevance to surgeons operating colon cancer[J]. Surg Endosc, 2022, 36(1): 100-108.
[6]	Zhao Z, Yao R, Yao Y, et al. Clinical application of three-dimensional printing technology in laparoscopic right hemicolectomy for colon cancer: a pilot study and video demonstration[J]. 3D Print Med, 2025, 11(1): 8.
[7]	卞琳杰, 陈义钢, 巫丹萍, 等. 3D打印技术在腹腔镜右半结肠癌根治术前评估中的应用价值[J]. 中华消化外科杂志, 2020, 19(7): 785-791.
[8]	Hojo D, Murono K, Nozawa H, et al. Improvement in Surgical Outcomes Using 3-Dimensional Printed Models for Lateral Pelvic Lymph Node Dissection in Rectal Cancer[J]. Dis Colon Rectum, 2022, 65(4): 566-573.
[9]	Zhao ZX, Hu ZJ, Yao RD, et al. Three-dimensional printing for preoperative rehearsal and intraoperative navigation during laparoscopic rectal cancer surgery with left colic artery preservation[J]. World J Gastrointest Surg, 2024, 16(10): 3104-3113.
[10]	Lu F, Qiu L, Yu P, et al. Application of a three-dimensional printed pelvic model in laparoscopic radical resection of rectal cancer[J]. Front Oncol, 2023, 13: 1195404.
[11]	Chen YG, Bian LJ, Zhou H, et al. Usefulness of three-dimensional printing of superior mesenteric vessels in right hemicolon cancer surgery[J]. Randomized Controlled Trial Sci Rep, 2020, 10(1): 11660.
[12]	Keller-Biehl L, Otoya D, Khader A, et al. Just the gastrointestinal stromal tumor: A case report of medical modeling of a rectal gastrointestinal stromal tumor[J]. SAGE Open Med Case Rep, 2024, 12: 2050313X231211124.
[13]	Povey M, Powell S, Howes N, et al. Evaluating the potential utility of three-dimensional printed models in preoperative planning and patient consent in gastrointestinal cancer surgery[J]. Ann R Coll Surg Engl, 2021, 103(8): 615-620.
[14]	Tominaga T, Takagi K, Takeshita H, et al. Usefulness Of Three- Dimensional Printing Models for Patients with Stoma Construction [J]. Case Reports Case Rep Gastroenterol, 2016, 10(1): 57-62.
[15]	To G, Hawke JA, Larkins K, et al. A systematic review of the application of 3D-printed models to colorectalsurgical training[J]. Tech Coloproctol, 2023, 27(4): 257-270.
[16]	Zhu Z, Amadi SM, Mao J, et al. A randomized cohort study on the use of 3D printed models to enhance surgical training in suturing techniques[J]. Sci Rep, 2025, 15(1): 636.
[17]	毛金磊, 竺志豪, 陈浩, 等. 3D打印模型在腹腔镜袖状胃切除术止血训练中的应用价值[J]. 中华消化外科杂志, 2023, 22(8): 1009-1013.
[18]	Chen YG, Qian CX, Shen RZ, et al. 3D Printing Technology Improves Medical Interns' Understanding of Anatomy of Gastrocolic Trunk[J]. J Surg Educ, 2020, 77(5): 1279-1284.
[19]	Ghazi A. A call for change. Can 3D printing replace cadavers forsurgical training?[J] Urol Clin North Am, 2022, 49(1): 39-56.
[20]	Chytas D, Noussios G, Salmas M, et al. Theeffectiveness of three-dimensional printing in undergraduate and postgraduateanatomy education: A review of reviews[J]. Morphologie, 2024, 108(361): 100759.
[21]	郑春雷, 王玉龙, 赵晶莹, 等. Sandwich教学法联合3D打印技术在肿瘤外科临床见习中的应用价值[J]. 中国医学装备, 2019, 16(1): 110-113.
[22]	Lin C, Huang ZP, Wang QL, et al. 3D Printed Bioinspired Stents with Photothermal Effects for Malignant Colorectal Obstruction[J]. Research(Wash DC), 2022, 2022: 9825656.
[23]	Wang J, Zhuang Z, Zhou J, et al. 3D printing and intelligent technology increase convenience, reliability, and patient acceptance of ostomy nursing: a randomized controlled trial[J]. Updates Surg, 2024, 76(6): 2211-2219.
[24]	蒋运罡, 黄金健, 刘野, 等. 3D打印肠瘘支架封堵肠空气瘘的疗效分析[J]. 中华胃肠外科杂志, 2021, 24(10): 904-909.
[25]	蔡晖, 王语嫣, 庄雷岚. 多学科结构化查房模式联合3D打印技术在老年胃造瘘患者中的应用研究[J]. 老年医学与保健, 2023, 29(04): 816-822.
[26]	Lee DS, Ahn JY, Lee GH. A Newly Designed 3-Dimensional Printer-Based Gastric Hemostasis Simulator with Two Modules for Endoscopic Trainees(with Video)[J]. Gut Liver, 2019, 13(4): 415-420.
[27]	Walter BM, Hann A, Frank R, et al. A 3D-printed cap with sideoptics for colonoscopy: a randomized ex vivo study[J]. Endoscopy, 2017, 49(8): 808-812.
[28]	Rodríguez-García JI, Sierra-Velasco JM, García-Santos G, et al. Transanal endoscopic surgery with a 3D printed device[J]. Tech Coloproctol, 2021, 25(8): 965-969.
[29]	中华医学会骨科学分会, 中国医师协会骨科医师分会, 中国中西医结合医师协会骨伤科医师分会. 骨科3D打印技术临床应用指南[J]. 中华骨科杂志, 2024, 44(12): 787-795.
[30]	LaBonia GJ, Lockwood SY, Heller AA, et al. Drug penetration and metabolism in 3D cell cultures treated in a 3D printed fluidic device: assessment of irinotecan via MALDI imaging mass spectrometry[J]. Proteomics, 2016, 16(11-12): 1814-1821.
[31]	Oladeji SA, Dadou SM, Zhao M, et al. The development and optimisation of gastro-retentive floating tablets using fused deposition modelling 3D printing[J]. J Pharm Pharmacol, 2022, 74(10): 1450-1466.
[32]	Mishra Y, Mishra V, Aljabali AAA, et al. 3D Printed Personalized Colon-targeted Tablets: A NovelApproach in Ulcerative Colitis Management[J]. Curr Drug Deliv, 2024, 21(9): 1211-1225.
[33]	Peng H, Han B, Tong T, et al. 3D printing processes in precise drug delivery for personalized medicine[J]. Biofabrication, 2024, 16(3): 10.
[34]	Mirdamadian SZ, Varshosaz J, Minaiyan M, et al. 3D printed tablets containing oxaliplatin loaded alginate nanoparticles for colon cancer targeted delivery. An in vitro/in vivo study[J]. Int J Biol Macromol, 2022, 205: 90-109.
[35]	Wang J, Chai S, Wang R, et al. Expert consensus on computed tomography-assisted three-dimensional-printed coplanar template guidance for interstitial permanent radioactive ¹²⁵I seed implantation therapy[J]. J Cancer Res Ther, 2019, 15(7): 1430-1434.
[36]	Ashenafi M, Jeong S, Wancura JN, et al. A quick guide on implementing and quality assuring 3D printing in radiation oncology[J]. J Appl Clin Med Phys, 2023, 24(11): e14102.
[37]	Xu HQ, Liu JC, Zhang ZY, et al. A review on cell damage, viability, and functionality during 3D bioprinting[J]. Mil Med Res, 2022, 9(1): 70.
[38]	Prashantha K, Krishnappa A, Muthappa M. 3D bioprinting of gastrointestinal cancer models: A comprehensive review on processing, properties, and therapeutic implications[J]. Biointerphases, 2023, 18(2): 020801.
[39]	Choi YM, Na D, Yoon G, et al. Prediction of Patient Drug Response via 3D Bioprinted Gastric Cancer Model Utilized Patient-Derived Tissue Laden Tissue-Specific Bioink[J]. Adv Sci(Weinh), 2025, 12(10): e2411769.
[40]	Zhang Z, Chen X, Gao S, et al. 3D bioprinted tumor model: a promptand convenient platform for overcoming immunotherapy resistance byrecapitulating the tumor microenvironment[J]. Cell Oncol(Dordr), 2024, 47(4): 1113-1126.
[41]	Taebnia N, Zhang R, Kromann EB, et al. Dual-material 3D-printed intestinal model devices with integrated Villi-like scaffolds[J]. ACS Appl Mater Interfaces, 2021, 13(49): 58434-58446.
[42]	Li J, Zhu T, Jiang Y, et al. Microfluidic printed 3D bioactive scaffolds for postoperative treatment of gastric cancer[J]. Mater Today Bio, 2023, 24: 100911.
[43]	Sabzevari A, Rayat Pisheh H, Ansari M, et al. Progress in bioprinting technology for tissue regeneration[J]. J Artif Organs, 2023, 26(4): 255-274.
[44]	Rizzo ML, Turco S, Spina F, et al. 3D printing and 3D bioprinting technology in medicine: ethical and legal issues[J]. Clin Ter, 2023, 174(1): 80-84.
[45]	Willson K, Atala A. Medical 3D Printing: Tools and Techniques, Today and Tomorrow[J]. Annu Rev Chem Biomol Eng, 2022, 13: 481-499.
[46]	Mandal A, Chatterjee K. 4D printing for biomedical applications[J]. J Mater Chem B, 2024, 12(12): 2985-3005.
[47]	Wei K, Tang C, Ma H, et al. 3D-printed microrobots for biomedical applications[J]. Biomater Sci, 2024, 12(17): 4301-4334.

Please choose a citation manager

Content to export